Shanghai Medicilon Inc.

  Medicilon  has a team of more than 100 chemists, and has experience in research and development cooperation with large pharmaceutical companies and biotechnology companies well-known at home and abroad. Under the leadership of experienced   medicinal chemistry   leaders, Medicilon provides customers with new drug development services covering a variety of targets and diseases, including from active compound discovery, target verification, lead compound optimization to the selection of preclinical drug candidates.   Details . Services : Primary and secondary screening of various ion channel drugs, discovery and optimization of lead compounds,  safety evaluation , and positioning of drug targets, etc. Detection method : automatic patch clamp or real-time fluorescence dynamic detection system Ion channels  are one of the cornerstones of living organisms to maintain normal functions. The bioelectric signals mediated by them play a key role in all life processes such as heart beating, hor

  Analytical chemistry experiments  should use pure water, generally distilled water or deionized water. Some experiments require the use of double distilled water or higher specifications of pure water (for example, experiments in electroanalytical  chemistry , liquid chromatography, etc.). Pure water is not absolutely free of impurities, but the content of impurities is very small. Note: It is difficult to determine the true pH value in water of primary and secondary purity. Therefore, the range of its pH value is not regulated; in primary water, it is difficult to determine its oxidizable substances and evaporation residues, so it is not regulated. 1 distilled water Pure water obtained by removing non-volatile impurities from water by distillation is called distilled water. The same is the pure water obtained by distillation, and the type and content of impurities contained in it are also different. The water distilled with a glass distiller contains Na+ and SiO2- ions; while the pu

  Radioactive and non-radioactive ligand binding assays There are numerous types of ligand binding assays, both radioactive ligand binding assays and non-radioactive ligand binding assays.  As such, ligand binding assays are a superset of radio-binding assays, which are the conceptual inverse of radioimmunoassays (RIA). Some newer types are called “mix-and-measure” assays because they do not require separation of bound ligands. Ligand binding assays are used primarily in  pharmacology  for various demands. Specifically, despite the human body’s endogenous receptors, hormones and other neurotransmitters, pharmacologists utilize assays in order to create drugs that are selective or mimic, the endogenously found cellular components.  On the other hand, such techniques are also available to create receptor antagonists in order to prevent further cascades.  Such advances provide researchers with the ability not only to quantify hormones and hormone receptors, but also to contribute importan

  Endotoxins   are small, stable, bacterially-derived hydrophobic molecules which can easily contaminate labware and whose presence can significantly impact both in vitro and in vivo experiments. Their presence is detected by the limulus amebocyte lysate (LAL) assay which can detect down to 0.01   Endotoxin   Units (EU)/ml. Thorough cleanliness in labware, raw materials and in lab technique is required to substantially reduce   endotoxin   levels. Sigma’s ultrapure HyStem line of products is produced according to these guidelines, yielding a product that is suitable for demanding in vitro and in vivo experiments. The original LAL/TAL method is the gel clot method.  In this method equal amounts of a test sample, for instance an injectable chemotherapy solution and the gel clot LAL/TAL are mixed in a test tube.  The combined solution is incubated at 37 °C for 60 minutes.  After the incubation, the tube is inverted.  If sufficient  endotoxin  is present in the test sample, the solution wo