Shanghai Medicilon Inc.

Medicilon has established an innovative, flexible, and reliable Large Animal Pharmacodynamic Research Service Platform that focuses on large animal models such as non-human primates, dogs, rabbits, and miniature pigs. The platform not only offers standard disease model development services but is also skilled in customizing complex disease models to meet the diverse research needs of clients.  In addition, the platform provides a full range of services from drug screening and efficacy evaluation to safety assessment, helping clients accelerate the new drug development process. With the advent of the era of precision medicine and the deepening understanding of disease mechanisms, large animal models such as non-human primates, dogs, rabbits, and miniature pigs have shown unique advantages and value in key areas of drug development. Due to their higher physiological similarity to humans, these models are particularly valuable in the research of cardiovascular diseases, metabolic dis...

  Pain is a sensation. IASP definition of pain (1979): “An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.” Revised IASP definition of pain (2020): “An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage.” Pain, both acute and chronic, remains a significant health problem despite tremendous progress in understanding of its basic mechanisms. Throughout ages man has used many different remedies for pain relief，However, there are still some pain symptoms can’t be effectively alleviated, and because of different degrees of analgesic drug adverse reactions or efficacy intensity and duration is not ideal, the prevention and treatment of pain is still not up to the ideal degree. Therefore, scientific researchers continue to invest a lot of energy and financial resources, hoping to develop new drugs with stronger analgesic effec...