The phenomenon of oil precipitation is called “oiling”, also known as liquid-liquid demixing or liquid-liquid phase separation (LLPS). The solute-enriched phase produced by the oil separation process is called the oil phase, and the solute-rich phase is called the water phase. The frequency of oil separation in the test depends on the specific test conditions and the material system involved. Oil precipitation may be common under certain substances or reaction conditions, including: low melting point, relatively large relative molecular weight, polypeptides, cyclic lipopeptides; molecular species containing flexible structures, such as long carbon chains that are easy to rotate; and sugars. During the test, the phenomenon of oil separation may lead to inaccurate analysis results and affect the normal operation of the test such as the reaction rate slows down, product recovery is difficult, equipment is blocked, and other problems. ...
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