Shanghai Medicilon Inc.

  Scientists at the University of Massachusetts Medical School (UMMS) say they have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the  digestive system . This finding, based on studying calcium ion-controlled pathways in mice, may lead to new treatments for a host of digestive disorders, ranging from common gastroesophageal reflux disease (GERD) to swallowing disorders, incontinence, and pancreatitis.          ❖      Medicilon’s Digestive System Disease Models Medicilon can provide various animal models (including renal failure model, anemia animal model, gastric acid secretion animal model, and gastric ulcer model) to test drug effectiveness according to client needs. We can conduct tests on typical digestive system diseases, including gastric acid secretions, gastric ulcers, and renal failure, using rats as subjects.       The tea...

  Scientists from the Duke University School of Medicine have discovered a network of genes and genetic regulatory elements in the lining of the intestines that has stayed remarkably the same from fishes to humans. Many of these genes are linked to human illnesses, such as inflammatory bowel diseases, diabetes and obesity.          ❖      Medicilon’s Digestive System Disease Models Medicilon can provide various animal models (including renal failure model, anemia animal model, gastric acid secretion animal model, and gastric ulcer model) to test drug effectiveness according to client needs. We can conduct tests on typical digestive system diseases, including gastric acid secretions, gastric ulcers, and renal failure, using rats as subjects. The research (“Genomic Dissection of Conserved Transcriptional Regulation in Intestinal Epithelial Cells”), which appears in  PLOS Biology , marks fish as a model organism for studying how this o...

  So great a need for constipation relief, so few constipation remedies. If only the estimated 4 million Americans who suffer from constipation had more options, particularly since dietary interventions so often fail. Additional options, new research suggests, may finally be on their way, in the form of genetically engineered probiotics. According to researchers at the Mayo Clinic Center for Individualized Medicine, synthetic bacteria may spur the transit of food through the  digestive system . The researchers add that synthetic bacteria may work better than generic probiotics, which don’t work for everyone because the gut microbiome – the community of bacteria found within the stomach and intestines – is unique to each person. The synthetic bacteria produced by the Mayo scientists are genetically engineered to produce large amounts of the chemical tryptamine. These bacteria, the Mayo scientists report, “accelerated gastrointestinal transit” in a  mouse model of constipat...