Every animal model of disease comes with its own unique set of drawbacks. Yet, scientists continually push to improve the quality of animal models to recapitulate the physiological and molecular signatures of disease states. For decades, researchers have turned to mice whose immune systems have been “humanized” to respond in a manner similar to humans. Infectious diseases kill millions of people each year, but the search for treatments is hampered by the fact that laboratory mice are not susceptible to some human viruses. However now, a team at Princeton University has developed a comprehensive way to evaluate how immune responses of humanized mice measure up to actual humans. In the current study, the research team looked at the mouse and human immune responses to one of the strongest vaccines known, a yellow fever vaccine called YFV-17D. The comparison of these “vaccine signatures” showed that a newly developed humanized mouse developed at Princeton sh...
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