Shanghai Medicilon Inc.

  1 .  Preclinical drug research (1) Pre-clinical research content 1. Literature research includes drug name and naming basis, the purpose and basis of the topic. 2. Pharmacy research. Raw material technology research, formulation prescription and technology research, confirmation of chemical structure or component test, drug quality test, drug standard drafting and description, sample inspection, auxiliary materials,  stability test , packaging material and container related test, etc. 3.  Pharmacology  and  Toxicology Research . General pharmacology tests, main pharmacodynamic tests,  acute toxicity tests , long-term toxicity tests, allergic, hemolytic and local irritation tests, mutagenicity tests,  reproductive toxicity tests , carcinogenic toxicity tests, dependence tests, animals  Pharmacokinetic tests , etc. The  drug safety evaluation  research must implement the “Pharmaceutical Non-Clinical Research Quality Management Stand...

  Former Fierce Markets writer and current independent writer Arsalan Arif recently published the latest   ranking of global  CRO companies . Let me share with you here that the ranking is based on market value. The data source is mainly based on the financial reports of listed companies, while the unlisted companies are estimated by reliable information sources (unit: billion US dollars). Since the founding of our company in 2004,  Medicilon has grown into one of the professional  drug discovery contract research organizations (CRO)  in China.  Global CRO Value Market Ranking Quintiles  has undoubtedly continued to rank No. 1 in the market value ranking of CRO companies. Dennis Gillings co-founded Quintiles with several other partners in 1982. Quintiles has since been involved in clinical trials of pharmaceutical companies. With expertise and expertise in clinical trials, business capabilities surpassed employers, and soon became one of the few C...

Medicilon provide  preclinical animal studies  for clients. Animal studies of drug efficacy are an important resource for designing and performing clinical trials. They provide evidence of a drug’s potential clinical utility, inform the design of trials and establish the ethical basis for testing drugs in human. Several recent studies suggest that many preclinical investigations are withheld from publication. Such non-reporting likely reflects that private drug developers have little incentive to publish preclinical studies. However, it potentially deprives stakeholders of complete evidence for making risk/benefit judgments and frustrates the search for explanations when drugs fail to recapitulate the promise shown in animals. Preclinical Trial  – A laboratory test of a new drug or a new medical device, usually done on animal subjects, to see if the hoped-for treatment really works and if it is safe to test on humans. Preclinical Animal Studies • In Vitro Toxic...

The use of rodents as a model for human cancer has been an important tool in the development and translation of innovative anti-cancer therapies. The service that we provide makes use of xenograft tumor models in immune deficient (nu/nu) mice, as well as transgenic and conditional/knock-in based engineered models that target known tumor promoting pathways. Genetic and phenotypic characterization of both xenograft tissue and genetically engineered animals allows the correlation of drug-target interaction, as well as the ability to test predictions of pathway-targeted anti-tumor efficacy. To test synergistic activity, novel therapeutics—generated both from within UCSF as well as externally—are tested alone and in rational combinations and dosing sequences. Tumor response to therapeutics is detected by a combination of direct tumor measurement and molecular imaging methods. Cell/tissue culture and engraftment The PTC has expertise in high volume cell culture, and maintains a larg...