Shanghai Medicilon Inc.

   It isn’t exactly earth-shaking news that a number of inflammatory diseases, including Crohn’s disease and ulcerative colitis, commonly occur together in individuals and families. Also, it has long been suspected that these inflammatory processes emanate from a shared fault, either environmental or genetic. But now, thanks to a global survey, the subterranean connection has finally been revealed. It is mainly genetic.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has been deeply involved in this field for years, developing reliable animal-based effi...

    NIH researchers report the discovery of a rare and sometimes lethal inflammatory disease – otulipenia – that primarily affects young children. They have also identified anti-inflammatory treatments that ease some of the patients’ symptoms: fever, skin rashes, diarrhea, joint pain, and overall failure to grow or thrive.              Otulipenia is caused by the malfunction of OTULIN, a single gene on chromosome 5. When functioning properly, OTULIN regulates the development of new blood vessels and the mobilization of cells and proteins to fight infection. The researchers published their study (“Biallelic Hypomorphic Mutations in a Linear Deubiquitinase Define Otulipenia, an Early-onset Autoinflammatory Disease”) in PNAS.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there ...

  Targeting a single enzyme that diverts the respiratory cycle in activated macrophages could offer new hope for treating inflammatory conditions, such as arthritis, sepsis, and autoimmune diseases. Scientists at the U.K.’s Imperial College Faculty of Medicine and Queen Mary University of London (QMUL) and Ergon Pharmaceuticals in the U.S. have shown that a drug in preclinical development by Ergon effectively reduces   inflammation   in rodent models of rheumatoid arthritis and severe kidney inflammation by decreasing macrophage infiltration.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. O...

  Researchers at the University of California San Diego (UCSD), School of Medicine discovered that they can block   inflammation   in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the arteries, and liver disease, and prolonged their lives. The study (“Oxidized Phospholipids Are Proinflammatory and Proatherogenic in Hypercholesterolaemic Mice”) published in  Nature , marks the first demonstration in a living system that OxPL triggers inflammation and leads to plaque formation, according to the researchers, who add that the results also suggest a new approach for preventing or reversing a number of inflammatory diseases.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis ...