Shanghai Medicilon Inc.

  Company Profile: Medicilon's  peptide synthesis research  team is closely focused on the topic of  peptide drug research  and is committed to solving the core problems that limit the development and application of peptide drugs. To improve the downstream peptide drug signal transduction pathways and mechanisms of action to improve the system. Through multi-disciplinary cooperation and intersections in chemistry, biology, medicine, and pharmacy, outstanding achievements have been made in basic and applied research.          ❖      Medicilon’s Synthetic Chemistry Services Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds. Related Articles: Medicilon Drug Discovery - Chemistry Department Join Medici...

  As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals or   synthetic organic compounds , effective monomers extracted from natural drugs, or antibiotics obtained by fermentation. In the future, the development of chemically synthesized drugs presents the following development trends: Discover new lead compounds from medicinal plants, modify their structures, and invent new drugs Chinese herbal medicine has been used for thousands of years, and very valuable experience has been obtained in the treatment of various diseases including tumors. Abundant Chinese herbal medicine resources also provide an important material basis for the search for new anti-cancer dru...

  In 1883, E. Fischer and F. Jourdan treated pyruvate with 1-methylphenylhydrazone with HCl alcohol solution to obtain 1-methylindole-2-carboxylic acid. After this discovery, the Fischer indole synthesis reaction became a very significant method for the synthesis of substituted indoles. The Fischer indole synthesis reaction is a simple and rapid synthesis method for arylhydrazones obtained from the reaction of aldehydes or ketones with arylhydrazones.  The drug discovery of Medicilon mainly include chemistry (synthetic chemistry, medicinal chemistry) and biology. Among them, our chemistry team can undertake multi-dimensional business cooperation such as custom synthesis of compunds, compound library construction, SAR compound synthesis and screening, compound structure and biological activity optimization. This reaction is followed by cyclization to generate polysubstituted indoles. The phenylhydrazone generated in the reaction is heated and rearranged under acid catalysi...

 Many people are curious about chemically synthesized drugs. In fact, in our lives, most of them are chemically synthesized drugs. The common ones are aspirin (acetylsalicylic acid), phenacetin, benzocaine, compound methoxy Naming and others. So how are they produced? The production methods of chemically synthesized drugs include total chemical synthesis, semi-synthesis, and chemical synthesis combined with microbial (enzyme-catalyzed) synthesis. What are the specific chemically synthesized drugs and what are the production methods of chemically synthesized drugs? Take a look at the article! 1. What are chemically synthesized drugs ? Chemically synthesized drugs refer to chemically synthesized drugs that are researched and produced according to chemical laws under the guidance of chemical theory. Generally speaking, it has a quick curative effect and a clear effect on disease treatment. The human body is a complex system, and chemically synthesized drugs lack the analysis and ...

  Chiral drugs   refer to drugs that contain chiral centers (including chiral carbon, chiral nitrogen, chiral sulfur, etc.) in their molecular structure. In January 1992, the FDA promulgated the “Development of Stereoisomer Drugs” technical research guidelines, giving guidance on the work that needs to be done in the research of stereoisomer drugs. In December 2006, the CFDA issued the “Technical Guidelines for the Quality Control of Chiral Drugs”, which provided detailed guidance on the research work that needs to be carried out in the   synthesis process , structural confirmation and quality control research of chiral drugs, and indicated for the research of chiral drugs. Up the direction. As a special kind of chemical drugs, chiral drugs should not only follow the “Guiding Principles for the Research of Chemical Drug Preparation Processes”, but also combine the introduction of chiral centers to establish appropriate process control indicators for monitoring. The config...

     The Efficient Chemistry Team Delivering on Time The Medicilon Chemistry Department is a professional, efficient, and well-qualified R&D team. The team has more than 40% of employees with a master's degree, doctor's degree, or above. Dr. Ma Xingquan, vice president of the chemistry department, graduated from the famous State Key Laboratory of Life and Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. , the National Institutes of Health), and an associate researcher at the world's top authoritative academic institution Scripps Research Institute (TSRI, The Scripps Research Institute), on the frontier fields of sugar chemistry, phospholipid chemistry, and polyphenol chemical biology. He has conducted in-depth research in other areas. He has published more than 20 academic papers in domestic and foreign core journals, including JACS, ANEW, LANGMUIR, OBC, JMCL, etc. At the same time, he has conducted in-depth research on ADC drug...

synthetic chemistry In-depth and flexible application of organic chemistry knowledge and skills The reasonable and efficient design of compound synthesis pathways Protect the IP-related rights and interests of customers and ensure the authenticity and integrity of data. medicinal chemistry In-depth cross-direction of chemistry and biology for each program Extensive use of advanced drug discovery technologies Extensive experience in innovative designs and patent strategies Responsive project management approach and effective communication biology Rich knowledge reserve and project experience Rapid follow-up and application of new technologies Establishment of various popular target test models Fast and reliable test data presentation Our Team The company employs nearly 2,000 people. Nearly 80% of employees have a bachelor's degree or above. Master and Ph.D. accounted for nearly 25%

  Recently, Pfizer's new crown-specific drug Paxlovid and the national miracle drug Ibuprofen are the most popular drugs in the medical circle. Today we will talk about the synthesis and mechanism of action of Ibuprofen, an evergreen drug! Recently, Ibuprofen has been hard to find, and it has become a well-known hard currency. Ibuprofen Ibuprofen, molecular formula C13H18O2, chemical name 2-(4-Isobutylphenyl) propanoic acid. Ibuprofen is a commonly used non-steroidal anti-inflammatory drug (NSAID). By inhibiting cyclooxygenase and reducing the synthesis of prostaglandins, it produces analgesic and anti-inflammatory effects; it acts as an antipyretic through the hypothalamic thermoregulatory center effect. Ibuprofen is generally well tolerated and does not cause clinically significant acute liver injury.  Ibuprofen chemical struture  Indications for Ibuprofen Oral administration: used to relieve mild to moderate pain, such as arthralgia, neuralgia, muscle pain, migraine, h...

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in  Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense muta...