Shanghai Medicilon Inc.

Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications? • Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐ Prodrugs. • Excretion – How is the drug eliminated? • Pharmacokinetics is concerned with the variation in drug concentration with time as a result of absorption, metabolism, distribution and excretion – Drug dose, route of administration, administration, rate and extent of absorption, absorption, distribution distribution rate (particularly to site of action) and rate of elimination. – Pharmacokinetics may be simply defined as what the body does to the drug. – Pharmacodynamics defined as what the drug does to the body. in vivo ADME Services We conduct a range of studies in rats and mice (other species are possible), including: • Pharma...