Shanghai Medicilon Inc.

  Organic synthesis is not only highly specialized but also "labor-intensive." Many workers in the field of organic synthesis laugh at themselves that their daily work is "moving bricks." In contrast, small molecule synthesis automation will greatly liberate productivity. However, due to the lack of general standards, only individual reactions can be automated, such as the automatic synthesis of oligopeptides, oligonucleotides, and oligosaccharides, as well as the MIDA-boronate-based Suzuki-Miyaura coupling reaction of Martin Burke's group. All of these methods are based on successive iterations of a small number of strong responses, and as such, they generally cannot be programmed, and the unit operations cannot be reused.   Medicilon’s Synthetic Chemistry Services Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synt...

What is synthesis? Synthesis refers to transforming a substance with a relatively simple composition into a sense with a complex design through a chemical reaction. Together with decomposition and replacement, it is also called three types of a chemical reactions. What is chemical synthesis? Chemical synthesis, also known as chemical synthesis, synthetic chemistry is the foundation and core of organic chemistry, inorganic chemistry, medicinal chemistry, polymer chemistry, material chemistry, and other disciplines. This course mainly introduces new concepts and new methods in the field of inorganic synthesis and organic synthesis. The organic synthesis part explicitly teaches the basic knowledge of organic synthesis and route design, modern organic synthesis methods, green synthetic chemistry, biomimetic synthesis, etc. The role of inorganic synthesis mainly teaches high-temperature synthesis, low-temperature solid-phase synthesis chemistry, hydrothermal and solvothermal synthesis, high...

  Organic synthetic chemistry is the core course of applied chemistry, chemistry, chemical engineering, and other majors. Organic synthetic chemistry involves a wide range of knowledge and rich content, covering all unit reactions and the formation and transformation of chemical bonds.   Medicilon’s Synthetic Chemistry Services Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds. Green chemistry  is an emerging discipline, covering many disciplines such as chemistry, materials, biology, pharmacy, environment, etc. It has clear social needs and scientific goals. According to reasonable reaction mechanisms and methods, it can reduce or eliminate the impact of the chemical industry on the environment from the source. To ensure that the reagents, cata...

  A team of Russian scientists led by Prof. Alexander Kiselyov from MIPT has synthesized an antitumor compound that can be used against chemotherapy-resistant cancers. The findings were published in the European Journal of Medicinal Chemistry. The scientists synthesized a new series of compounds called Aminoisothiazole and evaluated their anticancer effects using sea urchin embryos and human cancer cells. One of the molecules was shown to be potent and selectable. Among the 37 compounds synthesized, 12 have different potencies to reduce the proliferation rate of cancer cells or completely prevent their division, resulting in the death of cancer cells. The action of these antineoplastic compounds is attributed to their ability to destroy microtubules involved in cell division (mitosis). Microtubules are made of a protein called tubulin, which can be targeted by anticancer agents, causing degradation of the microtubule structure. The efficacy of  synthetic compounds  target...

    It is estimated that the cost of developing a new drug is about $ 2.6 billion, which is noticeable. However, much of this is spent on endless experiments and failures. Although a drug starts from the period of the pupae to the final approval, there are countless failures in the middle, and only some people have reflected on whether drug research and development need to be carried out in a way.         The era of "AI+Drug R & D" is coming      For a long time, drug research and development has had the characteristics of a long time, high investment, high risk, and slow investment reporting. The world's tens of billions of dollars are used in drug research and development every year.         There are many ways to "AI+Drug R & D." The core is to scan a large number of scientific papers published by the NLP algorithm, the scientific papers published by a large number of chemical databases, medical databases, and c...

    From September 9th to 10th, 2019, Suzhou CMC-EXPO China was successfully launched 2019. Dr. Ma Jianguo, Vice President of the Ministry of Crafts Department of the Ministry of Technology, will give a speech, "The Application of Green Chemical Technology in the Pharmaceutical Industry." Here we interview Dr. Ma in advance. In the interview, Dr. Ma gave us knowledge about green chemistry's research and development and production strategies and introduced its impact on the administration research circle.     Jianguo Ma     Vice President of CMC Department     Dr. Jianuo Ma, Vice President of the CMC of Shanghai Meidicilon, Bachelor and Master of Chemistry at the Department of Chemistry of Lanzhou University, Ph.D. at the UNIVERSITY of Montreal University, and postdoctoral chemistry at Harvard University. Dr. Ma has many years of research and development experience in a new types of drugs, leaders, and participation in several major innovative drug...

  The rapid development of a vaccine is critical to the ongoing fight against COVID-19. However, there are always challenges, such as the constant emergence of new variants. Therefore, developing antiviral therapies is also an important approach to addressing the ongoing threat of COVID-19. Pfizer's Paxlovid (Paxlovid) oral drug for the new crown will be launched for the first time at the end of 2021. Until February this year, the official website of China's State Food and Drug Administration released the important news of the drug's import registration, which will be included in the medical insurance payment system shortly. The time was sensational. It is worth mentioning that, for the preclinical research and development of anti-COVID-19 drugs, on one hand, Medicilon has already established a complete  mRNA vaccine bioanalysis technology platform ; It can provide professional pre-prescription services and lead compounds into late-stage development. Medicilon's pre-pre...