Shanghai Medicilon Inc.

  Drug metabolism refers to the chemical change process of drugs in the body. Most drugs lose their activity after being metabolized, and are converted into extremely high water-soluble metabolites, which are beneficial to excretion from the body. There are also some drugs that are hardly metabolized in the body and are excreted as original drugs.   For more details, please read  Factors Affecting Pharmacokinetics of Drugs . The metabolism of drugs requires the participation of enzymes. The liver is an important organ for drug metabolism. The cytochrome P-450 enzyme system of liver microsomes is the main enzyme system that promotes drug metabolism, so it is called liver drug enzymes. Some drugs can also be decomposed by related enzymes in other tissues. The availability and content of liver drug enzymes are not unstable, and individual differences are large, and they are easily affected by certain drugs. Any drug that can enhance the activity of liver drug enzymes or acce...

DMPK     or Drug Metabolism and  Pharmacokinetics   is a major part of studies related to drugs often referred to as   ADME   (Absorption, Distribution, Metabolism and Elimination). It is concerned with the study of aspects of absorption, distribution, metabolism and elimination of drug compounds which are administered through any route of administration. Drug Metabolish and Pharmacokinetics are specific to  drug discovery ; drug properties such as route of administration, dose level, dose regimen and  formulation , drug-drug interactions and specific populations are all tightly related to  DMPK  and are therefore measured by our experts. Our  DMPK  Department is dedicated to the understanding of the absorption, distribution, metabolism and excretion of drug candidates. Medicilon’s Pharmacokinetics Services Medicilon’s  pharmacokinetics  department offers the clients a broad spectrum of high quality of services in the...

Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications? • Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐ Prodrugs. • Excretion – How is the drug eliminated? • Pharmacokinetics is concerned with the variation in drug concentration with time as a result of absorption, metabolism, distribution and excretion – Drug dose, route of administration, administration, rate and extent of absorption, absorption, distribution distribution rate (particularly to site of action) and rate of elimination. – Pharmacokinetics may be simply defined as what the body does to the drug. – Pharmacodynamics defined as what the drug does to the body. in vivo ADME Services We conduct a range of studies in rats and mice (other species are possible), including: • Pharma...

Medicilon has synthesized over 10,000 individual compounds from gram to kilogram quantities, and many compounds are synthesized with more than ten synthetic steps. The overall synthesis success rate is over 95%. High quality products from mg to kg scale Reagents, intermediates, building blocks, and scaffolds Preparation of API or reference standards Development of synthetic routes for impurities and metabolites   On-site analytical support Product delivered with COA Medicilon offers integrated drug discovery services -- Chemistry, Biology & Preclinical Services

Medicilon ’s Preclinical department has extensive and professional knowledge in drug metabolism/pharmacokinetics, pharmacology studies as well as toxicology . We offer high-quality and  cost-effective data with rapid turnaround time to support drug development, preclinical studies and clinical research. Our services cover various aspects of preclinical services, including protocol designing, in-life studies, sample analysis, professional data analysis, IACUC review, and preparation of documents for IND filing. Over 50%  of our employees have MS and PhD degrees, and over 10% of our employees have significant foreign education and/or working experiences. Medicilon and MPI Research established a joint venture from 2008-2010 to set up a state-of-the-art 50,000 Sq. ft. animal facility fully accredited by AAALAC and in compliance with US GLP and China FDA GLP. Our services facilitate the evaluation of the safety and marketing of life-changing compounds for our clients.