Shanghai Medicilon Inc.

 Medicilon's pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME , in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules , such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and etc. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Available PK studies include : Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies,  Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB  penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability Prediction and identification of major metabolites Toxicokinetics analysis Distribution studies In vivo Medicilon offer...

For the development of innovative drugs, the process consists of three stages and four steps: target discovery, characterization and evaluation (biological target phase); Discovery and optimization of lead compounds ( drug discovery phase); ADMET (absorption, distribution, metabolism, excretion and toxicity), PK, PD studies ( drug discovery and development phase ); clinical trial ( drug development stage ). High Throughput ADME Study of New Drug Discovery The use of high-throughput ADME screening technology can quickly identify the lead compounds, but by combining the chemical structure of the compound library, the first is the problem of poor structural diversity, which reduces the success rate of compound development; followed by compounds of poor drug resistance, so that a large number of Compounds were eliminated during ADME screening, increasing the cost of the experiment. Over the past 20 years, although new technologies have emerged in the drug discovery phase, there has bee...

Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications? • Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐ Prodrugs. • Excretion – How is the drug eliminated? • Pharmacokinetics is concerned with the variation in drug concentration with time as a result of absorption, metabolism, distribution and excretion – Drug dose, route of administration, administration, rate and extent of absorption, absorption, distribution distribution rate (particularly to site of action) and rate of elimination. – Pharmacokinetics may be simply defined as what the body does to the drug. – Pharmacodynamics defined as what the drug does to the body. in vivo ADME Services We conduct a range of studies in rats and mice (other species are possible), including: • Pharma...

Pharmacokinetics Services Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Preclinical Pharmacokinetics Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability CYP 450 inhibition Plasma protein binding studies Distribution studies Excretion studies Prediction an...