By performing biopsies on target organs, researchers can gain in-depth insights into the metabolism and distribution characteristics of a drug within specific tissues or organs. This enables a more accurate evaluation of the drug’s efficacy and safety, thereby assisting in the optimization of drug design. Different administration methods, such as local delivery and targeted delivery, can influence drug absorption, bioavailability, and the suitability of specific experiments. In PK studies, special administration methods may increase drug concentration in the target tissue, enhance therapeutic effects, or reduce the incidence of adverse reactions. Yufeng Meng, the Assistant Director of DMPK at Medicilon, provides insights on the techniques and applications of target organ biopsy in PK studies. This information aims to help reduce confusion and challenges in PK trials. 1. Are there any requirements for selecting liver lobes during the puncture process? If so, what ar...
Integrated Drug Discovery Services- Chemistry, Biology & Preclinical Services