Intraocular Drug Delivery Barriers Intraocular drug delivery barriers mainly include tear film, cornea, conjunctiva, sclera, choroid, blood-retinal barrier, and blood-aqueous humor barrier. The fast-flowing tears in the tear film can dilute and wash away the drugs placed on the surface of the eye; the particular sandwich structure of the cornea makes it the function of limiting the penetration of lipophilic and hydrophilic drug molecules at the same time; the fast-flowing blood can quickly clear the conjunctiva, episclera, and Drugs in the choroid tissue; while the blood-aqueous humor barrier and the blood-retinal barrier together constitute the barrier system between blood vessels and the entire ocular tissue, limiting the exchange of substances between blood vessels and ocular tissues. [1] Solutions, suspensions, emulsions, gels, and ointments are common topical ophthalmic formulations. Traditional ophthalmic formulations often have low bioavailability. Most eye diseases are treate...
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