April 6, 2023 Table of Contents Small Molecule Drugs : Antibody-Drug Conjugates Small Molecule Drugs : RNA targeting small molecules Small Molecule Drugs : PROTAC Summarize Small molecule drug discovery has led to numerous medical breakthroughs that have transformed the treatment of various diseases such as Cancer, viral infections, Neurodegenerative diseases, etc. In the future, with the continuous advancement of science and technology, the development of small-molecule drug discovery continues to hold great promise for the development of new treatments and the promotion of medical breakthroughs. Drug discovery is a complex and challenging task, from “target identification” to “lead identification” when compounds show activity against biological targets, from “target identification” when pharmacokinetics (ADME) and potency are optimized Lead Optimization,” and finally to “Candidate Drug Selection” when selecting clinical candidates for safety studies. The entire process ca...
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