Shanghai Medicilon Inc.

  March 9, 2023 Table of Contents 1. Computer-aided prediction model 2. In vitro high-throughput screening models 3. In vivo screening models In innovative drug development, conducting  toxicology studies  to determine the type, dose, and mechanism of toxic response to a drug is essential to deciding on a drug’s safety and efficacy, developing safe drug use strategies, and avoiding unnecessary drug toxicities. Generally, drug toxicology research includes the following : Toxicity testing : drug toxicity tests are conducted in experimental animals or cells to assess the harmful effects of drugs on organisms. Mechanism of toxicity studies : To understand the causes of toxic reactions by studying the mechanism of action of drugs. Toxicity assessment : To assess drug safety and potential risks and develop reasonable drug use strategies. Toxicological monitoring : to monitor the population using the drug and understand the long-term toxicity and adverse effects. In the early st...

Medicilon provide  preclinical animal studies  for clients. Animal studies of drug efficacy are an important resource for designing and performing clinical trials. They provide evidence of a drug’s potential clinical utility, inform the design of trials and establish the ethical basis for testing drugs in human. Several recent studies suggest that many preclinical investigations are withheld from publication. Such non-reporting likely reflects that private drug developers have little incentive to publish preclinical studies. However, it potentially deprives stakeholders of complete evidence for making risk/benefit judgments and frustrates the search for explanations when drugs fail to recapitulate the promise shown in animals. Preclinical Trial  – A laboratory test of a new drug or a new medical device, usually done on animal subjects, to see if the hoped-for treatment really works and if it is safe to test on humans. Preclinical Animal Studies • In Vitro Toxic...