March 9, 2023 Table of Contents 1. Computer-aided prediction model 2. In vitro high-throughput screening models 3. In vivo screening models In innovative drug development, conducting toxicology studies to determine the type, dose, and mechanism of toxic response to a drug is essential to deciding on a drug’s safety and efficacy, developing safe drug use strategies, and avoiding unnecessary drug toxicities. Generally, drug toxicology research includes the following : Toxicity testing : drug toxicity tests are conducted in experimental animals or cells to assess the harmful effects of drugs on organisms. Mechanism of toxicity studies : To understand the causes of toxic reactions by studying the mechanism of action of drugs. Toxicity assessment : To assess drug safety and potential risks and develop reasonable drug use strategies. Toxicological monitoring : to monitor the population using the drug and understand the long-term toxicity and adverse effects. In the early st...
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