Shanghai Medicilon Inc.

  “ ADME ” or “Toxicokinetics” is the process of studying the body’s absorption, distribution, metabolism, and excretion of foreign chemicals. Medicilon Drug Safety Evaluation Service >> Toxicokinetic absorption, distribution, metabolism, excretion The  toxicokinetics study  used repeated doses of the toxicity test dose to study the dynamic changes of drugs in vivo, and obtained  pharmacokinetic  data. It is usually carried out in conjunction with repeated administration of toxicity tests. If appropriate parameters are determined, repeated tests can be avoided.  Toxicokinetics  is an integral part of the design of non-clinical trials. In understanding the results of toxicity studies and comparing them with clinical data to evaluate safety for humans, the focus is on interpreting the results of toxicity tests and increasing the value of  safety assessment data . The purpose of the toxicokinetics study is to know the degree and duration of sys...

  Medicilon’s   pharmacokinetics   department offers the clients a broad spectrum of high quality of services in the areas of in   vitro ADME , in   vivo pharmacokinetics   and   bioanalysis services , ranging from   small molecules   to   large molecules , such as protein and antibody. The   animal species   involved in our services are non-human primate, canine, mice, rat, rabbit and etc. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Available PK Studies Include : Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies,  Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB  penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability Prediction and identification of major  meta...

  In vitro metabolism studies can exclude the interference of the body factors for the overall experiment to provide a reliable theoretical basis for the low metabolic rate in vivo, toxic and lack of sensitive detection means of drugs, in vitro metabolism research is a good means of research. At present, in vitro models of drug metabolism include microsomal models, gene recombination enzyme models, hepatocyte models, hepatobiliary perfusion models, Liver tissue sections and so on. Metabolic stability is a key drug property, which is important for both drug administration regiment design as well as toxicity. Species comparison in metabolic stability allows the determination of which animal species is the most appropriate model for the estimation of human metabolic stability of the test article. The use of liver microsomes allows the evaluation of metabolic stability as results of phase I oxidation. The use of hepatocytes allows the evaluation of both phase I oxidation and phase II c...

 Medicilon's pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME , in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules , such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and etc. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Available PK studies include : Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies,  Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB  penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability Prediction and identification of major metabolites Toxicokinetics analysis Distribution studies In vivo Medicilon offer...

For the development of innovative drugs, the process consists of three stages and four steps: target discovery, characterization and evaluation (biological target phase); Discovery and optimization of lead compounds ( drug discovery phase); ADMET (absorption, distribution, metabolism, excretion and toxicity), PK, PD studies ( drug discovery and development phase ); clinical trial ( drug development stage ). High Throughput ADME Study of New Drug Discovery The use of high-throughput ADME screening technology can quickly identify the lead compounds, but by combining the chemical structure of the compound library, the first is the problem of poor structural diversity, which reduces the success rate of compound development; followed by compounds of poor drug resistance, so that a large number of Compounds were eliminated during ADME screening, increasing the cost of the experiment. Over the past 20 years, although new technologies have emerged in the drug discovery phase, there has bee...

Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications? • Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐ Prodrugs. • Excretion – How is the drug eliminated? • Pharmacokinetics is concerned with the variation in drug concentration with time as a result of absorption, metabolism, distribution and excretion – Drug dose, route of administration, administration, rate and extent of absorption, absorption, distribution distribution rate (particularly to site of action) and rate of elimination. – Pharmacokinetics may be simply defined as what the body does to the drug. – Pharmacodynamics defined as what the drug does to the body. in vivo ADME Services We conduct a range of studies in rats and mice (other species are possible), including: • Pharma...

ADME studies - ADME is an abbreviation in pharmacokinetics and pharmacology , stands for absorption, distribution, metabolism and elimination of chemicals and drugs to define the impact in a human body. Toxicology testing is a significant event before an introduction of new drugs into the market. However, drug development is a very crucial stage of the pharmaceutical and biotechnology manufacturer as it is attributed to high costs at the various stages of drug development. Thus, one of the key factors linked to the last stage drug failure is due to inability of new drug candidates to meet human and animal safety profile . In order to overcome this barrier of drug failure, ADME toxicology testing has a major advantage to enter in early drug development phase of preclinical trials . ADME toxicology testing influence the drug levels and kinetics of drug exposure to the body tissue and hence facilitated the performance in pharmaceutical manufacturing by minimizing drug discovery time,...