Compound stability is an important factor to consider during the early stages of drug discovery . We have a leading portfolio of compound stability services designed to help you understand the metabolic profile of your compounds. The aim of metabolic stability study is measuring the disappearance rate of a chemical compound. The half-life, in vitro clearance measured from metabolic stability assay can be used to predict hepatic clearance, and also to evaluate dose, toxicity, oral bioavailability, etc. For instance, if a drug is rapidly metabolized when entering to the body, it may require more daily dosing to maintain its blood or tissue concentrations in order to get an ideal therapeutic effect. On the other hand, if a drug is slowly metabolized, the dose need to be adjusted and more preclinical toxicity tests should be conducted as long-time exposure may cause toxic build-up. Many compounds with promising pharmacological characteristics never become drugs due...
Integrated Drug Discovery Services- Chemistry, Biology & Preclinical Services