Shanghai Medicilon Inc.

Type 2 diabetes is a progressive disease. The disease course is primarily characterized by a decline in β-cell function and worsening of insulin resistance. Therefore, various antidiabetic agents are under research and development. The hypoglycemic strategy has also shifted from "sugar control" to both "sugar control" and "heart protection". GLP-1R agonists can improve left ventricular ejection fraction, myocardial contractility, coronary blood flow, cardiac output, and endothelial function while reducing infarction size and overall risks for a cardiovascular event. Other functions of GLP-1 include increased glucose uptake in the muscles, decreased glucose production in the liver, neuroprotection, and increased satiety due to direct actions on the hypothalamus. At present, the therapeutic application and potential value of GLP-1RAs in diabetes has become a research hotspot. In the formulation of GLP-1 integrated research plan, Medicilon has in-depth commun...

  Introduction In vitro  recombinant protein production  is a protein obtained by applying recombinant DNA or recombinant RNA technology. Catalog The use of in vitro protein expression technology to extensively produce various types of recombinant proteins, which are used in the fields of medicine, food, daily chemical and other fields. The following briefly introduces the main expression systems of the main recombinant proteins. Escherichia coli expression system Escherichia coli  has a clear genetic background, low cost, multiple vectors and hosts to choose from. It is not only the most commonly used expression system, but also the most economical protein expression system. The expression system is optimized, such as the compatibility test of the expression vector and the expression strain. , The optimization of induced expression conditions, renaturation, etc., can greatly solve the difficult problems of protein expression and insoluble protein expression. Suitabl...