Shanghai Medicilon Inc.

By performing biopsies on target organs, researchers can gain in-depth insights into the metabolism and distribution characteristics of a drug within specific tissues or organs. This enables a more accurate evaluation of the drug’s efficacy and safety, thereby assisting in the optimization of drug design.  Different administration methods, such as local delivery and targeted delivery, can influence drug absorption, bioavailability, and the suitability of specific experiments.  In PK studies, special administration methods may increase drug concentration in the target tissue, enhance therapeutic effects, or reduce the incidence of adverse reactions. Yufeng Meng, the Assistant Director of DMPK at Medicilon, provides insights on the techniques and applications of target organ biopsy in PK studies. This information aims to help reduce confusion and challenges in PK trials. 1. Are there any requirements for selecting liver lobes during the puncture process? If so, what ar...

  The main aim of drug development is to get a compound that has a therapeutic effect into the form of a medicine we can dose to patients that is safe and effective. A drug must reach the site of action in a quantity sufficient to exert its pharmacological effects, and be eliminated in a reasonable timeframe. DMPK, an acronym that stands for drug metabolism and pharmacokinetics, considers how the drug is metabolized and processed by the body. Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. ADME test results can be used to predict how the drug will behave in the body and to assess its potential for adverse interactions with other drugs. Bioanalytical support plays a vital role during the lead optimization stages. The major goal of the bioanalysis is to assess the over-all ADME characteristics of the NCEs and biologics. Bioanaly...