Scientists report that fruit flies inhibited from producing the protein Sirt4 are short-lived, while flies modified to make extra Sirt4 are live longer. Flies lacking Sirt4 show increased sensitivity to starvation, decreased fertility and activity, and an inability to use energy stores in their bodies, add the researchers, who say their work suggests that increasing Sirt4 activity may be an important approach for treating age-related metabolic decline and disorders , such as diabetes and obesity. ❖ Medicilon’s Endocrine & Metabolic Disease Models Services In the field of metabolic diseases, we are proud of our portfolio of stable and effective animal models, especially those for Non-alcoholic Fatty Liver Disease (NAFLD). Though popular recently, they still lack effective drug treatment. Their study (“Sirt4 Is a Mitochondrial Regulator of Metabolism and Lifespan in Drosophila melanogaster”) is published in ...
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