Shanghai Medicilon Inc.

Recently, Huizhou Jizhong Biological Technology’s innovative drug local anesthetic injection - a new long-acting postoperative analgesic successfully obtained FDA (US Food and Drug Administration) new drug clinical trial approval! The new long-acting postoperative analgesic was completed by Shanghai Medicilon in its full set of  preclinical safety evaluation research ,  preclinical pharmacology ,  pharmacokinetics  and other projects. Anesthetics include general anesthetics, local anesthetics, narcotic analgesics, and muscle relaxants. Among them, local anesthetics are a class of drugs that are applied locally around nerve endings or nerve trunks, which can temporarily, completely and reversibly block the generation and conduction of nerve impulses, and temporarily disappear local pain sensation under conscious conditions. . Because local anesthetics are easy to use and have no damaging effects on various tissues, they have been widely recognized by clinicians. Curre...

For the development of innovative drugs, the process consists of three stages and four steps: target discovery, characterization and evaluation (biological target phase); Discovery and optimization of lead compounds ( drug discovery phase); ADMET (absorption, distribution, metabolism, excretion and toxicity), PK, PD studies ( drug discovery and development phase ); clinical trial ( drug development stage ). High Throughput ADME Study of New Drug Discovery The use of high-throughput ADME screening technology can quickly identify the lead compounds, but by combining the chemical structure of the compound library, the first is the problem of poor structural diversity, which reduces the success rate of compound development; followed by compounds of poor drug resistance, so that a large number of Compounds were eliminated during ADME screening, increasing the cost of the experiment. Over the past 20 years, although new technologies have emerged in the drug discovery phase, there has bee...

Medicilon's Pharmacology department functions in accordance with the needs of our customers for a variety of effective animal models used to detect drug effectiveness. We offer non-human primates, dogs, mice, and rats, rabbits, guinea pigs, amongst others in our services. At present, we have various proven effective animal models, furthermore, our staff’s rich experience operate with strong theoretical basis is while still being flexible enough for custom development of various types of models to meet the requirements of our clients. View more about medicilon's service, www.medicilon.com