Shanghai Medicilon Inc.

   Malaria parasites cause an inflammatory reaction that sabotages our body’s ability to protect itself against the deadly disease, scientists have found for the first time.     The finding opens up the possibility of improving malaria vaccines by boosting key immune cells needed for long-lasting immunity. This could even include vaccines that have previously been ineffective in clinical trials.     Researchers found that the same inflammatory molecules that drive the immune response in clinical and severe malaria also prevent the body from developing protective antibodies against the parasite.               ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical resear...

  Inflammation has always been a double-edged sword, providing critical action that helps heal wounds or thwart infections, in addition to damaging healthy cells and tissues due to a disproportionate response. Understanding the regulatory mechanisms that control the balance between positive and negative inflammation could open new   drug discovery   avenues for a variety of diseases and disease complications, such as sepsis.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has been deeply involved in this field for years, developing reliable animal-...