Shanghai Medicilon Inc.

  In theory, in vivo drug testing is the most important and reliable basis for evaluating drugs. However, in the   development of oral solid dosage forms , the method of measuring   bioavailability   is used to screen and evaluate each new prescription and process, which is time-consuming and costly. money. Although the results of in vivo and in vitro tests may not be completely consistent, they have certain relevance. Because the in vitro dissolution test is simple and feasible, it can be regarded as a cost-effective quality test and control method. The determination of in vitro dissolution rate can provide an important basis for the formulation of preparations and process screening, and avoid blindness in the research and development of solid preparations. solid dosage forms Medicilon provides R&D and production services for pharmaceutical preparations. According to the characteristics of the dosage form, combined with the physical and chemical properties and s...

  Bioavailability is defined as the rate and the absorption of drug that reaches the biological system in an active form, capable of exerting the desired pharmacological effect, including its onset, intensity and duration of its action. The Need for Bioavailability Studies Bioavailability studies provide and estimate of the fraction of the orally administered dose that is absorbed into the systemic circulation when compared to the bioavailability for a solution, suspension, or intravenous dosage form that is completely available Bioavailability studies provide other useful information that is important to establish dosage regimen and to support drug labeling, such as distribution and elimination characteristics of the drug Bioavailability studies provide information regarding the performance of the formulation Bioavailability Study Protocol The aim of bioavailability study is to find out the dosage form influence on the biological performance of the drug, sensitivity to detect diff...