April 3, 2023 Decade of Myths about CAR-T Therapy Recently, “CAR-T curative effect lasts for ten years” has been frequently searched in medical news! Professor Carl June, one of the CAR-T therapy experts, published an important paper on CAR-T therapy in the “Nature” magazine: the introduction of artificially synthesized CAR-T cells can be used in the periphery of leukemia patients who have survived for more than ten years without tumors. The blood is still detected, and these T cells are still active. Notably, the scientists observed two distinct phases of the anti-leukemic response: an initial phase characterized by CD8 + CAR-T cells, followed by a proliferative CD4 + CAR-T cell population in subsequent years. The composition of these cells changed intriguingly over time in both patients. In the early stage of treatment, CAR-T cells are mainly CD8 + T cells. CD8 T cells are T cells that express CD8 glycoprotein as a T cell receptor on the cell membrane, which a...
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