Shanghai Medicilon Inc.

  Medicilon is a   Preclinical Research Outsourcing   (CRO) company. With our more than 10 years experience on   preclinical research services , we dedicated to provide our clients with customized   preclinical services   program in drug metabolism,   pharmacokinetics , efficacy studies, and   toxicology . We provide our clients a high-quality data and rapid turnaround time to support their drug development, preclinical studies and clinical research and to help them to select the most valuable drug candidates into clinical trials stage. Our   preclinical research services   consist in three major parts: pharmacokinetics, disease transplantation models and   drug safety evaluation . Our   preclinical research services   cover all of the aspects including design, in vivo studies, sample analysis, professional data analysis, IACUC review, and the preparation of application materials. Preclinical Research Services Quick start ...

  Former Fierce Markets writer and current independent writer Arsalan Arif recently published the latest   ranking of global  CRO companies . Let me share with you here that the ranking is based on market value. The data source is mainly based on the financial reports of listed companies, while the unlisted companies are estimated by reliable information sources (unit: billion US dollars). Since the founding of our company in 2004,  Medicilon has grown into one of the professional  drug discovery contract research organizations (CRO)  in China.  Global CRO Value Market Ranking Quintiles  has undoubtedly continued to rank No. 1 in the market value ranking of CRO companies. Dennis Gillings co-founded Quintiles with several other partners in 1982. Quintiles has since been involved in clinical trials of pharmaceutical companies. With expertise and expertise in clinical trials, business capabilities surpassed employers, and soon became one of the few C...

Drug development  is time consuming and costly which contains  preclinical , clinical and after-market. In principle, if all the processes are straight-forward, a drug can be developed in a seven year period. In practice, drug development takes in excess of twelve years. Procedures are tightly regulated both for safety and to ensure drugs are effective. Of the many compounds studied with the potential to become a medicine, most are eliminated during the initial research phases. Clinical trials follow extensive research using in vitro and animal studies. Even so, many drugs are withdrawn or fail, never becoming approved as medicines. Common reasons include side-effects, the drug proving less effective than hoped or lacking financial viability. Overview of Development Process Drug Discovery Screening Pre-Clinical Testing IND Application Phase I Clinical Trials Phase II Clinical Trials Phase III Clinical Trials New Drug Application (NDA) / Biologics License Appli...

Pharmacokinetics Services Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Preclinical Pharmacokinetics Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability CYP 450 inhibition Plasma protein binding studies Distribution studies Excretion studies Prediction an...

Medicilon's toxicology department has professional teams with rich experience in toxicology studies. We offer high-quality data and rapid turnaround period to support drug discovery and development. Our toxicological studies are conducted in various animal species. The toxicological evaluation from dose design, in-life studies to histology and pathology testing along with toxicokinetics studies are all compliant with GLP or NON-GLP standards. Our study platform is certified as one of the Shanghai Public Service Research Platforms. Animal Facilities 50,000 Sq. ft.  total  area 12,500 Sq. ft. for function area 12,500 Sq. ft. for Canine housing: maximum capability for 350 canines 12,500 Sq. ft. for Nonhuman Primate housing: maximum capability for 400 NHPs 12,500 Sq. ft. for Barrier system for Rodent housing: Separate SPF and non-SPF area; maximum capability for 5000 animals of SPF area and 500 animals of non-SPF area Design and Operation of the facility are under in...