Medicilon has strong capability in assay development and compound screening . Our screening capacity could be 200x384 well/week,or customize it per clients' needs. We work closely with partners such as Selleck,MCE and Tocris that provide compound libraries, and we have more than a library of 3000 compounds in-house. In vitro enzymatic assays Screening cascade - inhibitors of small molecules Enzymatic assays Measurement of substrate reduction (ATP, NAD/NADP, SAM, Acetyl-CoA, peptide, DNA, RNA, etc.) - Down assay Measurement of products - Up assay Enzymatic assay - example 1 HTRF assay-Homogeneous Time Resolved Fluorescence Donor=Eu and Tb Acceptor=XL665 Pros： (1)Highly specific, high signal/background ratio； (2) Highly stable fluorescence signal; (3)Homogeneous reaction, high throughput. Cons： (1)Cost for specific antibody is relatively high; (2)Specific antibodies need to be developed for specific target. Enzymatic assay - example 2 ADP-Glo assay Pros： (1) Highl...
Integrated Drug Discovery Services- Chemistry, Biology & Preclinical Services