Could a mother’s diet and excess weight during pregnancy predispose her offspring to become obese and develop metabolic disorders and cardiovascular diseases later in life? U.S. researchers report on new molecular and genetic studies in baboons that support existing epidemiological evidence suggesting that maternal obesity (MO) may “preprogram” offspring to develop cardiometabolic diseases in adulthood by causing changes in key metabolic pathways in the developing fetal liver. ❖ Medicilon’s Endocrine & Metabolic Disease Models Services In the field of metabolic diseases, we are proud of our portfolio of stable and effective animal models, especially those for Non-alcoholic Fatty Liver Disease (NAFLD). Though popular recently, they still lack effective drug treatment. The results showed that baboon fetuses of obese baboon mothers who consume high-sugar, high-fat diets during pregnancy develop a fatty liver and exhibit signif...
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