Shanghai Medicilon Inc.

  What is the Main Purpose of Preclinical Testing? Pre-clinical testing must be performed before clinical trials. The purpose of pre-clinical trials is to use human cell cultures or animals to evaluate the potential toxicity of a new therapeutic drug before the “in vivo” test is performed by human participants. The main goals of preclinical studies are to determine a starting, safe dose for  first-in-human study  and assess potential  toxicity  of the product, which typically include new  medical devices ,  prescription drugs , and  diagnostics . According to the US Food and Drug Administration (FDA), before a new medicinal drug is approved for use, a series of tests need to be carried out. In the first phase, basic research identifies hypothetical targets to treat a certain disease and then small molecules or biological compounds are screened to find any which show potential to treat the disease. Before the new vaccine can be tested in humans,...

  Preclinical research refers to chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics and toxicology research, and pharmacy research conducted before the drug enters clinical research. Preclinical Trails Content Preclinical research of drugs for drug registration, including drug synthesis technology, extraction methods, physical and chemical properties and purity, dosage form selection, prescription screening, preparation technology, inspection methods, quality indicators, stability, pharmacology, toxicology, animal drugs Generation dynamics and so on. Traditional Chinese medicine preparations also include the source, processing and processing of raw medicinal materials, and biological products also include the source of starting materials, quality standards, storage conditions, biological characteristics, genetic stability, and immunology of bacteria, cell strains, biological tissues, etc. Research and so on. Accor...

  Medicilon offers prepackaged M9 selenomethionine ( SeMET ) growth media kits and packages for growing cell culture in IPTG-inducible bacterial expression systems, leading to the production of   SeMET -labeled proteins for crystallographic studies using MAD. SeMet Media for E.coli Growth Medicilon offers prepackaged M9 selenomethionine ( SeMET ) growth media kits and packages for growing cell culture in IPTG-inducible bacterial expression systems, leading to the production of  SeMET -labeled proteins for crystallographic studies using MAD.  The cell growth media kits are designed to simplify the procedures to grow cell culture in order to save your time and lower your cost. We have optimized the kits (see below) for structural genomics laboratories to speed up the protein structure production.  We can also make kits specially designed for you. These kits eliminate the need for sterilization and have no need for weighing out chemicals, by just adding k...

  The   Medicilon gene knockout service   has been successfully applied to model organisms such as cells, yeast, plants, zebrafish, mice, and rats. Gene knock-out is a technique for the targeted integration of foreign genes into a certain location on the genome of target cells through homologous recombination to achieve the purpose of targeted modification of a gene on a chromosome. It overcomes the blindness and chance of random integration, and is an ideal method to modify and transform biological genetic material. Gene knockout service CRISPR/Cas9 gene knockout mouse technical service Technical process: gRNA vector construction =>”gRNA and Cas9 transcribed into mRNA in vitro => “mRNA microinjection (produced by F0 model) Provide the following technical services:     All-inclusive services from gRNA vector construction to F0 model production     Customers provide Cas9 RNA and gRNA that meet quality requirements for subsequent microinj...

  The   yeast “two hybrid”   or “interaction trap” assay, is a technique used to study protein-protein interactions, which are critical in virtually all cellular processes. The study of protein-protein interactions can be divided into three major parts: • Identification of binding proteins • Characterization of known interactions • Potential to manipulate such interactions This technology is based on the fact that the activating domain (AD) and binding domain (BD) of a transcription factor can be separated and still function when they get into close proximity. Y2H screening is therefore designed to use a BD fused bait protein to screen against a library of AD fused prey proteins. The bait is usually a known protein that the researcher tries to identify new interacting partners with. The prey is usually a library of proteins to be screened from. When the bait protein binds to the prey protein, transcription of the specially designed reporter genes occurs and allows selecti...