LC-MS Analysis Service

LC/MS/MS Method Development & Validation

Development, transfer, and optimization of methods for quantification of drugs in biological matrices
Quick turnaround time to speed up the drug development process

Chemical Analytical Center of Medicilon provides general analysis and purification services for the clients. Our experts have rich experience and proficient skills to solve problems, which are highly appreciated by clients.

General Analytical Chemistry Services

– NMR 1D、2D（H-NMR、C-NMR、P-NMR、F-NMR、HSQC、HMBC、COSY、NOESY, et al）
– LC-MS Analysis
– HPLC Analysis (including ELSD)
– Chiral HPLC Analysis

– General LCMS Testing (ROI、LOD、Cl-、SO42-、mp、HM、Specific Rotation、Water Content, et al）

LC/MS Introduction

LC/MS is short for Liquid Chromatography / Mass Spectrometers.

Liquid Chromatography (LC) is a fundamental separation technique in the life sciences and related fields of chemistry. Unlike gas chromatography, which is unsuitable for nonvolatile and thermally fragile molecules, liquid chromatography can safely separate a very wide range of organic compounds, from small-molecule drug metabolites to peptides and proteins.

Mass Spectrometers (MS) also generate three dimensional data. In addition to signal strength, they generate mass spectral data that can provide valuable information about the molecular weight, structure, identity, quantity and purity of a sample. Mass spectral data add specificity that increases confidence in the results of both qualitative and quantitative analyses.

Why and When to Use LC/MS

The use of LC-MS in many application areas within analytical science continues to grow almost exponentially. Listed below are some pointers as to applicability of both HPLC as a separative technique and MS as a means of detecting analyte species.

Bioanalytical LC-MS method development for quantitative determination of drugs and their metabolites in biological fluids is crucial during drug development. The need for efficiently generated, regulatory compliant bioanalytical data is reliant on fit-for-purpose methods being developed and validated by experienced LC-MS scientists.

Our bioanalysis LC-MS teams are recognized for the ability to efficiently develop and validate routine and non-routine methods in a wide variety of matrices, and to rapidly employ these assays in a GLP-compliant and high throughput sample analysis environment.

lcms testing

Liquid Chromatography Mass Spectrometry System

Below is part of our current services in the Bioanalytical Department:

– Method Transfer and Optimization (LC-MS/MS and HPLC)
– Method Development and Validation (LC-MS/MS and HPLC)
– High Throughput Analysis to Support Discovery TK/PK/PD Studies
– Analytical Support for Clinical Trials
– Support for Preclinical TK/PK Studies
– Pharmacokinetic (PK) Studies
– Metabolite Identification
– Bioequivalence Studies

Contact Us

Email : marketing@medicilon.com
Tel : +86 021 58591500

Tips : Above is part of LC/MS analysis service, LC/MS testing price and LC/MS method development . You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

LC-MS Method Development and Validation

LC-MS/MS Method Development

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration. The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies, ADCs , mRNA vaccines , small nucleic acid drugs , PROTAC , and CGT technical service platform that have helped 421 INDs obtain clinical approval. It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

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What is Toxicokinetics?

Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms toxicokinetics , pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...

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