Shanghai Medicilon Inc.

  Medicilon’s   medicinal chemistry   involves the application of a number of specialized disciplinary approaches all focused on the ultimate goal of   drug discovery .    Drug target identification and validation , rational (target-based) drug design,   structural biology , computational-based drug design, methods development (chemical, biochemical and computational), and “ Hit-to-lead ” development are all aspects of medicinal chemistry.  The techniques and approaches of chemical biology,   synthetic organic chemistry , combinatorial (bio)chemistry, mechanistic enzymology, computational chemistry, chemical genomics and high-throughput screening are all used and applied by medicinal chemists towards drug discovery.   Medicilon has completed dozens of drug research projects for clients and successfully identified several drug candidates for clinical trials. Our team provides the following services: more details Target Assessment – Drug Targets HITs Identification Lead Optimization Clin

  Medicilon’s   chemical   department has comprehensive chemical research capabilities and facilities including medicinal chemistry, synthetic chemistry, process research and   analytical support , and professional synthetic technology. It has a good record of project advancement and the generation of preclinical drug candidates. We can quickly complete new drug development projects from compound screening to new drug clinical research declaration in a highly efficient and low-cost manner. Chemical FTE Service Our team is made up of a team of experienced chemists, who can provide customers with high-quality and efficient research services of various chemical molecular  synthesis . It can transform the small-scale synthesis method of the compound into a process route of several kilograms, which can ensure the completion of the project research within a very strict time limit. Chemical FTE services, synthesis of chemical intermediates and analogs, development and research of compound str

Medicilon provides a variety of   effective animal models   according to customer needs to test the effectiveness of drugs. Conventional endocrine diseases and metabolic diseases include: diabetes, obesity, dyslipidemia, etc. Animal experiments are conducted with large mice and hamsters. Endocrine and Metabolic Disease Model Disease model animal Diabetes Streptozotocin Diabetes Mice Spontaneous diabetes db/db, ob/ob mice Obese mice induced by high-fat diet DIO mice Obesity Hereditary db/db, ob/ob mice Obese mice induced by high-fat diet DIO mice Dyslipidemia High fat/cholesterol Hamster Contact us: Marketing@medicilon.com Tel: 02158591500 Animal model of diabetes Animal models of diabetes are us ually divided in to two types: inducible and spontaneous. There are also many ways to copy animal models of diabetes. In animal selection, mainly mammals, rodents are the most used and most widely used, mainly used for drug screening, pathological changes and other aspects of research. Rabbits

  Researchers from the University of Bristol say they have combined   synthetic biology and chemistry   to create a modern technology platform to allow the production of novel antibiotics to combat increasing microbial drug resistance. The team is working on derivatives of pleuromutilin, with the core pleuromutilin isolated from the mushroom  Clitopilus passeckerianus . Pleuromutilin derivatives are potent antibacterial drugs but often require difficult chemical modifications, according to the scientists. In a new paper (“Heterologous Expression Reveals the Biosynthesis of the Antibiotic Pleuromutilin and Generates Bioactive Semi-Synthetic Derivatives”), published in  Nature Communications , the Bristol researchers report the genetic characterization of the steps involved in pleuromutilin biosynthesis through heterologous expression and generate a semisynthetic pleuromutilin derivative with enhanced antibiotic activity.  This was achieved by taking the complete genetic pathway for pleu

The progress of  medicinal chemistry  and a large number of new drugs listed in the late 20th century, mainly summarized as two reasons: 1) Life sciences, such as structural biology, molecular biology, molecular genetics, genetics and biotechnology, to provide theoretical basis and technical support for the discovery of new drugs; 2) the rapid development of scientific information such as the establishment of bioinformatics, the development of biochips, the application of various information kiosks and information technology, can easily retrieve and search the required literature and the research level and efficiency greatly improved. In order to strive for the international market, pharmaceutical companies invested a lot of money for new drug research and development; new varieties of drugs continue to promote the rapid development of the pharmaceutical industry. We will usher in the new century of knowledge economy in the near future. Knowledge innovation, technological innovation, s