Drug Bioavailability Studies from Medicilon

Bioavailability is defined as the rate and the absorption of drug that reaches the biological system in an active form, capable of exerting the desired pharmacological effect, including its onset, intensity and duration of its action.

The Need for Bioavailability Studies

Bioavailability studies provide and estimate of the fraction of the orally administered dose that is absorbed into the systemic circulation when compared to the bioavailability for a solution, suspension, or intravenous dosage form that is completely available
Bioavailability studies provide other useful information that is important to establish dosage regimen and to support drug labeling, such as distribution and elimination characteristics of the drug
Bioavailability studies provide information regarding the performance of the formulation

Bioavailability Study Protocol

The aim of bioavailability study is to find out the dosage form influence on the biological performance of the drug, sensitivity to detect differences in the rate and extent of absorption.

Study Objective
Study Design
Methods of assessment of bioavailability plasma data and urine data acute pharmacological effect and clinical response
Analysis and Presentation of Data

Types of Bioavailability

Absolute Bioavailability – Absolute bioavailability of a drug in a formulation administered by an extravascular, including the oral route reaching the systemic circulation is the fraction of the same dose of the drug administered intravenously.
Relative Bioavailability – Relative bioavailability is a measure of the fraction of the given drug that is absorbed in the systemic circulation from a particular dose compared to a clinically proven standard dose of the same drug.

Assessment of Bioavailability

For assessing the bioavailability or clinical availability of a drug, its rate and extent of absorption and its first-pass metabolism must be evaluated.
These criteria are difficult or even impossible to quantify.
The method used to assess bioavailability depend upon the assumption that measurement of the drug concentration in a suitable body fluid, such as blood, plasma, serum, urine or sometime saliva, can be correlated with its clinical availability.

Contact Us

Email : marketing@medicilon.com
Tel : +86 021 58591500

Tips: Above is part of drug bioavailability studies. You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

Analysis on the role of drug dissolution test in the determination of human bioavailability

Three Ways to Improve the Bioavailability of Poorly Soluble Drugs

Spray Drying Method for Improving the Bioavailability of Poorly Soluble Compounds

Bioavailability research

Custom Synthesis

Medicilon has synthesized over 10,000 individual compounds from gram to kilogram quantities, and many compounds are synthesized with more than ten synthetic steps. The overall synthesis success rate is over 95%. High quality products from mg to kg scale Reagents, intermediates, building blocks, and scaffolds Preparation of API or reference standards Development of synthetic routes for impurities and metabolites On-site analytical support Product delivered with COA Medicilon offers integrated drug discovery services -- Chemistry, Biology & Preclinical Services

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In Vitro Enzyme Activity Assay

Kinases play extensive and important roles in signal transduction and co-ordination of complex functions. Currently, about 300 kinase inhibitors have been approved for marketing, among which receptor tyrosine kinase (RTK) inhibitors are the main ones. Medicilon provides high-quality kinase profile screening and has one-stop kinase research services from assay development, high-throughput screening to selectivity analysis. In addition, Medicilon provides many other enzyme activity screens. Wide Variety Provides 200+ in vitro enzymatic detection methods; 100+ kinases, including CTK, RTK, AGC, CMGC and other kinase families as well as important common mutations Project Flexibility Various types of plates for screening, such as 96 and 384; Multiple flexible kinase profiles, including TK kinase family, CDK kinase family, etc., to meet different customer customization needs. Various Methods Fluorescence detection; Chemiluminescence detection; Absorbance detection LanthaScr...

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Pharmacokinetics Services

Pharmacokinetics Services Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Preclinical Pharmacokinetics Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability CYP 450 inhibition Plasma protein binding studies Distribution studies Excretion studies Prediction an...

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