Medicilon's Drug ADME/PK Assays Services

Medicilon's pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and etc. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government.

Available PK studies include:

Method development and validation (GLP,Non-GLP)
Bioanalysis
Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration )
Stability in vehicles and plasma
Drug interaction studies
In vitro metabolic stability
Prediction and identification of major metabolites
Toxicokinetics analysis
Distribution studies

In vivo
Medicilon offers a suite of in vivo ADME services and features a team with over 12 years of experience. We are equipped to conduct in-life studies in rat ,pig , mouse and dog. We provide comprehensive radiolabel ADME study support across non-clinical species.
Available studies include:

Excretion Studies
Tissue Distribution
Plasma Protein Binding Studies
Others……

Bioanalysis:

Advanced bioanalytical method development
Advanced bioanalytical method validation
Pharmacokinetics
Others……

In vitro
With extensive knowledge of in vitro ADME and pharmacokinetics gained through working within drug discovery environments at both pharmaceutical and biotech companies, our ADME experts offer a consultative approach ensuring that the right experiments are performed at the right time.

ADME Assays SERVICES has been created with the objective to give support on pharmacokinetics and metabolism studies to small and mid-size pharmaceutical and biotech companies involved in research and development of new drugs or new formulations.

• Absorption ‐ route of drug delivery
• Distribution ‐ where does the drug go, where does it need to go and what
are the implications
• Metabolism Metabolism ‐ this will occur and could impact several several variables variables
• Excretion – how is the drug eliminated

• Pharmacokinetics is concerned with the variation in drug concentration with time as a result of absorption, metabolism, distribution and excretion
– Drug dose, route of administration, administration, rate and extent of absorption, absorption, distribution distribution rate (particularly to site of action) and rate of elimination
– Pharmacokinetics may be simply defined as what the body does to the drug
– Pharmacodynamics defined as what the drug does to the body

These pharmacokinetic processes, often referred to as ADME, determine the drug concentration in the body when medicines are prescribed.

Contact US

Email : marketing@medicilon.com
Tel : +86 021 58591500

Tips : Above is part of drug adme assays , adme study services and pharmacokinetics adme Services. You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

Preclinical ADME Studies

Factors Affecting Pharmacokinetics of Drugs

High-throughput ADME research in the new drug discovery phase

ADME Pharmacokinetics Studies

High Throughput ADME Study of New Drug Discovery

Drug absorption, distribution, metabolism and excretion (pharmacokinetics)

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration. The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies, ADCs , mRNA vaccines , small nucleic acid drugs , PROTAC , and CGT technical service platform that have helped 421 INDs obtain clinical approval. It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

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What is Toxicokinetics?

Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms toxicokinetics , pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...

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