Shanghai Medicilon Inc.

  Medicilon relies on its strong drug innovation technology strength, integrates the company's internal superior resources, and joins forces among departments to build a platform for Medicilon's peptide drug conjugate (PDC) research and developmen t into a technologically with advanced platform, complete supporting facilities and functions and standardized operation. It can form a comprehensive innovative drug research and development platform with integrated innovation capabilities, develop and provide key technologies, and can provide services such as the research and innovative peptide drugs, new peptide dosage forms, and peptide generic drugs. In 1913, German Nobel Prize winner Paul Ehrlich proposed the concept of magic bullet.  The toxin (bullet) is installed on a carrier that can accurately target cancer cells, thereby accurately killing cancer cells without harming normal cells.  This idea was considered a fantasy at that time. In 1989, Professor Andrew v. Schally,...

  Recently, Shanghai Huaota Biopharmaceutical Co., Ltd. (Huaota) received a notification from the US FDA, agreeing that the third-generation antibody drug conjugate (ADC) project HB0052 developed by the company targeting the CD73 antigen will enter clinical trials.  This is the first antibody conjugate drug project approved by Huaota Biotech to enter clinical trials by the FDA. As a partner of Huaota, Shanghai Medicilon Inc. (Medicilon) relied on its antibody drug conjugate R&D service platform and its professional technical capabilities and rich project experience to provide HB0052 with R&D of the drug metabolism and safety evaluation tests that complied with GLP standards to ensure high-quality and efficient advancement. Medicilon Antibody Drug Conjugate R&D Service Platform  Pressing the "Accelerator Button" for ADC Drug Development As one of the rare one-stop biopharmaceutical preclinical R&D service platforms in China, Medicilon has established an...

   Scientists at the University of Alberta have developed a new method of controlling biology at the cellular level using light. The tool–called a photocleavable protein–breaks into two pieces when exposed to light, allowing scientists to study and manipulate activity inside cells in new and different ways.     First, scientists use the photocleavable protein to link cellular proteins to inhibitors, preventing the cellular proteins from performing their usual function. This process is known as caging.     “By shining light into the cell, we can cause the photocleavable protein to break, removing the inhibitor and uncaging the protein within the cell,” said lead author Robert Campbell, Ph.D., professor in the Department of Chemistry. Once the protein is uncaged, it can start to perform its normal function inside the cell.     The tool is relatively easy to use and widely applicable for other research that involves...

  Molecular  biology   is the science of studying life phenomena and the essence of life at the molecular level. The   molecular biology technology   provided by some   molecular biology service   organizations is a more advanced and cutting-edge technology in life science research. Molecular docking is a key technology in structural molecular biology and has played an increasingly important role in computer-aided drug design in recent years. Molecular docking technology is a computer-based analysis that can apply mathematical, biological and computer models to predict the affinity of small molecules for specific receptors. Molecular docking technology  can predict the binding affinity of  new chemical entities (NCEs)  or drugs based on their chemical structure. In the field of innovative drug research, computer-aided drug design technology, which combines computer technology, optimization methods and drug design, plays an important role...

  Glycobiology is the study of the structure, biosynthesis, and   biology  of saccharides (sugar chains or glycans) that are widely distributed in nature.  Sugars or saccharides are essential components of all living things and aspects of the various roles they play in biology are researched in various medical, biochemical and biotechnological fields. Scientists at the Van Andel Research Institute and the City University of New York have described the atomic-level structure of a molecular complex responsible for modifying proteins. They believe their work could lead to the development of new therapeutics for cancer and other diseases. The complex, known as OST, or oligosaccharyltransferase, plays an important role in protein glycosylation. “The determination of the atomic-level structure of OST is a breakthrough in glycobiology,” said Huilin Li, Ph.D., a professor at Van Andel Research Institute (VARI) and senior author on a study (“The Atomic Structur...

Drug administration route is often classified by the location at which the drug is administered, such as oral or intravenous. The choice of routes in which the medication is given depends not only on convenience and compliance but also on the drug's pharmacokinetics and pharmacodynamic profile. Therefore it is crucial to understand the characteristics of the various routes and associated techniques as the first step before PK/PD, efficacy/pharmacology and toxicity study. Intravenous Injection (i.v.) Intravenous injection directly delivers the drugs to the systemic circulation. It is utilized when a rapid drug effect is desired, a precise serum drug level is needed, or when drugs are unstable or poorly absorbed in the gastrointestinal tract. It is also the route used in patients with altered mental status or severe nausea or vomiting, unable to tolerate oral medications. Advantages: Rapid onset of action Predictable way of action and almost complete bioavailability The problems of ...