Analytical Chemistry and Its Application Scope

Do you know the Analytical Chemistry and Its Application Scope? The main task of Analytical Chemistry is to identify the chemical composition (elements, ions, functional groups, or compounds) of the substance, to determine the content of the relevant components of the substance and the structure of the substance (chemical structure, crystal structure, spatial distribution), the existence of the form (valence state, coordination state, crystalline state) and its relationship with the nature of the material, mainly for structural analysis, morphological analysis, energy analysis.

Field of application of Analytical Chemistry: Analytical chemistry has a very high practical value, made an important contribution to the material civilization of mankind, widely used in geological survey, mineral exploration, metallurgy, chemical industry, energy, agriculture, medicine, clinical laboratory, environmental protection, commodity inspection, Archaeological analysis, forensic criminal investigation and other fields.

Analytical methods should be simple, not only field work (such as geological survey, chemical prospecting, environmental monitoring, soil testing, etc.) but needs simple and effective chemical analysis methods and indoor routine analysis work as well.

Because the method is simple and the steps are small without compromising the required accuracy and precision, this means saving time, manpower and expense. For example, the gold shop to buy gold jewelry, it is in the test stone slabs (scientific name is stripes), and then from the color of the stripes to identify the fineness of gold. This striping method is still used in mineral identification.

Of course, this method is less than the fire test method or atomic absorption spectrometry accurate, but has been able to achieve the purpose of identification of gold. Another example, the urine of urine can be measured with a special enzyme-containing test paper, from the color of the test paper to estimate the amount of sugar content; the method is simple and evens the patient. On the other hand, atomic absorption spectrometry can also indirectly measure the amount of sugar in the urine sample, but because it is not economical and not been used.

Chemical Analytical Center of Medicilon provides general analysis and purification services for the clients. Our experts have rich experience, proficient skills to solve problems, which are highly appreciated by clients.

Analytical Chemistry Services Including:

Featured Services – Impurity Analysis

Impurity Isolation by Pre-HPLC
Impurity Identification by 1D/2D NMR、LCMS、EA、HRMS、IR、UV et al
Isolation and Identification of Degradation Byproduct of API
Q-NMR Analysis

IND Package Preparation

Development and Validation of Analytical Methods (Complying with guidelines of CP, USP, EMA, ICH et al)

Methods of Purity and Assay
Methods of Residue Solvents
Methods of Chiral Purity

Methods of Heavy Metal

General Analytical Chemistry Services

NMR 1D、2D（H-NMR、C-NMR、P-NMR、F-NMR、HSQC、HMBC、COSY、NOESY, et al）
LC-MS Analysis
HPLC Analysis (including ELSD)
Chiral HPLC Analysis
General Testing (ROI、LOD、Cl-、SO42-、mp、HM、Specific Rotation、Water Content, et al ）

For more information, please visit our website, www.medicilon.com

What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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