Shanghai Medicilon Inc.

 Stress, anxiety and depression are closely related to the phenomenon, most of the anxiety and depression patients have experienced severe psychological stress events. Thus, stress events are seen as a cause of anxiety and depression, or at least on genetic basis, which can lead to the generation of emotional disorders. Anxiety and Depression Animal models place animals in a series of stress situations (latent or actual threats, acute or chronic) that cause emotional disorders and then apply specific measures to behavioral and physiological indicators Detection, and thus explore the mechanisms of this emotional disorder, as well as the identification and screening of anxiolytics or antidepressants. Anxiety Animal Model: Anxiety is a pre-known but inevitable, upcoming stress events caused by an expected response to fear, fear, tension and other psychiatric symptoms as the main performance, accompanied by palpitations, sweating, cold hands and feet and other plant neurological disorders

 When battling emerging infectious diseases, finding a model that accurately recapitulates the pathogenesis of the infection is critical to developing effective therapeutic interventions. Yet, as most scientists can attest, the things that are the most critical are also most often the most difficult to obtain. An alternative animal model that mimics key features of the Zika virus infection, including its lingering presence in bodily fluids, has been developed at Texas Biomedical Research Institute in San Antonio. Findings from the new study were published recently in S cientific Reports , in an article entitled “Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection.” The research team found that acute infections in male marmosets, a New World monkey, resemble the human illness the Zika virus creates in people, including the presence of the virus in semen, saliva, and urine up to two weeks after the initial infection. The prima

 Medicilon provides a variety of effective animal models according to customer needs to test the effectiveness of drugs. Conventional endocrine diseases and metabolic diseases include: diabetes, obesity, dyslipidemia, etc. Animal experiments are conducted with large mice and hamsters. Endocrine and Metabolic Disease Model Disease model animal Diabetes Streptozotocin Diabetes Mice Spontaneous diabetes db/db, ob/ob mice Obese mice induced by high-fat diet DIO mice Obesity Hereditary db/db, ob/ob mice Obese mice induced by high-fat diet DIO mice Dyslipidemia High fat/cholesterol Hamster Contact us: Marketing@medicilon.com Tel: 02158591500 Animal model of diabetes Animal models of diabetes are us ually divided in to two types: inducible and spontaneous. There are also many ways to copy animal models of diabetes. In animal selection, mainly mammals, rodents are the most used and most widely used, mainly used for drug screening, pathological changes and other aspects

  Medicilon Animal Tumor Model Tumor animal models can be divided into three categories: Animal model of spontaneous tumor Induced tumor animal model Transplantation tumor animal model 1. Spontaneous tumor animal model : without human treatment; naturally occurring Overall evaluation of spontaneous tumors-The etiology of spontaneous tumors in animals is often determined by the genetic characteristics of the animal, which is far away from the cause of human cancer. The growth rate of tumors varies greatly among animals, and it is difficult to obtain a large number of tumor-bearing animals within a limited time. Therefore, animal models of spontaneous tumors are rarely widely used in routine screening of anti-tumor drugs. 2. Animal model of induced tumor : under experimental conditions; use of carcinogens induce tumors in animals (animal model of induced tumor) refers to an animal model that uses carcinogens to induce animal tumors under experimental conditio

 Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, and guinea pigs. At present, we have established a number of effective animal models, and have passed multiple verifications and long-term practical tests. At the same time, our employees' rich experience and strong theoretical foundation can flexibly develop and build various customized models according to customer's customization requirements to meet customer needs. Tumor disease model Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, guinea pigs, and nude mice . At present, we have established a number of effective animal tumor models , and have passed multiple verifications and long-term practical tests. At the same time, our employees&

Medicilon is the leading Preclinical Contract Research Organization (CRO), providing bioanalytical cro services to the global biopharmaceutical markets. Our protein analytical services could identify a protein by molecular weight, sequence confirm the primary structure of a protein and detect post translational modifications, characterize a protein by aggregation, thermostability, size, charge, and pI, measure a protein's purity/impurity, determine the amino acid sequences of a purified protein sample or discover the amino acid sequence of an antibody, compare one protein or antibody sample to a second sample or biosimilar molecule, and more. Bioanalytical Services for Preclinical Studies: Bioanalytical Method Development and Validation Dose Formulation Analysis Bioanalysis of Preclinical and Clinical Samples Test Articles: Small Molecules and Large Molecules , including Protein, DNA, RNA, Vaccines Biomarker Analysis Small Molecule Bioanalytical Services: International C

  Process Analytical Science Our process analytical sciences group provides support for research, development and commercial production. At Medicilon, the importance of analytical support in pharmaceutical development and manufacturing is well understood.  We provide our clients with analytical method development and all other services required to support their regulatory needs. Services Offered Analytical Method Development, Qualification and Validation For Assay Related Compounds Water Content Chiral Analysis Residual Solvents Trace Metals Analysis IPC and Release Testing Impurity Isolation and Structure Elucidation Reference Standard Qualification Stability Studies PGI Method Development, Validation and Testing Specification and Other Regulatory Filing Documentation Preparation We have the following key instrumentation to support our analytical activities Chromatography: UPLC, HPLC, LC-MS, GC, GC-HS Solid State Characterization: DSC, TGA, XRPD, PSD, Polari

 Medicilon's pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME , in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules , such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and etc. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Available PK studies include : Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies,  Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB  penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability Prediction and identification of major metabolites Toxicokinetics analysis Distribution studies In vivo Medicilon offers a suite

For the development of innovative drugs, the process consists of three stages and four steps: target discovery, characterization and evaluation (biological target phase); Discovery and optimization of lead compounds ( drug discovery phase); ADMET (absorption, distribution, metabolism, excretion and toxicity), PK, PD studies ( drug discovery and development phase ); clinical trial ( drug development stage ). High Throughput ADME Study of New Drug Discovery The use of high-throughput ADME screening technology can quickly identify the lead compounds, but by combining the chemical structure of the compound library, the first is the problem of poor structural diversity, which reduces the success rate of compound development; followed by compounds of poor drug resistance, so that a large number of Compounds were eliminated during ADME screening, increasing the cost of the experiment. Over the past 20 years, although new technologies have emerged in the drug discovery phase, there has bee

Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications? • Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐ Prodrugs. • Excretion – How is the drug eliminated? • Pharmacokinetics is concerned with the variation in drug concentration with time as a result of absorption, metabolism, distribution and excretion – Drug dose, route of administration, administration, rate and extent of absorption, absorption, distribution distribution rate (particularly to site of action) and rate of elimination. – Pharmacokinetics may be simply defined as what the body does to the drug. – Pharmacodynamics defined as what the drug does to the body. in vivo ADME Services We conduct a range of studies in rats and mice (other species are possible), including: • Pharma

ADME studies - ADME is an abbreviation in pharmacokinetics and pharmacology , stands for absorption, distribution, metabolism and elimination of chemicals and drugs to define the impact in a human body. Toxicology testing is a significant event before an introduction of new drugs into the market. However, drug development is a very crucial stage of the pharmaceutical and biotechnology manufacturer as it is attributed to high costs at the various stages of drug development. Thus, one of the key factors linked to the last stage drug failure is due to inability of new drug candidates to meet human and animal safety profile . In order to overcome this barrier of drug failure, ADME toxicology testing has a major advantage to enter in early drug development phase of preclinical trials . ADME toxicology testing influence the drug levels and kinetics of drug exposure to the body tissue and hence facilitated the performance in pharmaceutical manufacturing by minimizing drug discovery time,