跳至主要内容

Medicilon Human Disease Animal Model

 Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, and guinea pigs. At present, we have established a number of effective animal models, and have passed multiple verifications and long-term practical tests. At the same time, our employees' rich experience and strong theoretical foundation can flexibly develop and build various customized models according to customer's customization requirements to meet customer needs.

animal model

Tumor disease model

Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, guinea pigs, and nude mice. At present, we have established a number of effective animal tumor models, and have passed multiple verifications and long-term practical tests. At the same time, our employees' rich experience and strong theoretical foundation can flexibly develop and build various customized tumor disease models according to customer's customization requirements to meet customer needs. see more

Type of cancer (tumor model)Cell line
Head and neck tumor modelKB, FaDu
Animal model of nasopharyngeal carcinoma
Stem cell animal model 		S18, S26
Lung cancer animal modelsDMS114, NCI-H69, NCl-H146, NCl-H209, NCI-H446, NCI-H526, NCI-H1688, 95-D, A549, Calu-1, Calu-3, Calu-6, HCC827, NCI -H226, NCI-H292, NCI-H358, NCI-H441, NCI-H460, NCI-H520, NCI-H522, NCI-H1299, NCI-H1437, NCI-H1650, NCI-H1975, NCI-H1993, NCI-H2009 , NCI-H2122, NCI-H2126, NCI-H2228, PC-10, QG-56
Breast cancer animal modelsSUM159, MDA-MB-231, MDA-MB-468, Bcap-37, 2LMP, ZR-75-1, ZR-75-30
Animal model of gastric cancerMKN-45, NCI-N87, BGC-823, HGC-27, MKN-28, NUGC-3, SCH, SGC-7901, SNU-5, SNU-16, MGC-803
Animal model of pancreatic cancer AsPC-1, BxPC-3, Capan-1, Capan-2, CFPAC-1, HPAF-II, MIAPaCa-2, PANC-1
Kidney cancer animal modelACHN, OS-RC-2, 786-O
Liver cancerBel-7402, Hep-3B, Huh-7, PLC/PRF/5, QGY-7703, SK-HEP-1, SMMC-7721, HepG-2
Glioblastoma U87-MG
Colon and cecum cancersCOLO 201, COLO 205, COLO 320 DM, CW-2, DLD-1, HCT-8, HCT-15, HCT-116, HCT116 P53 K0(-/-), HT-29, LoVo, LS1034 , LS174T, LS411N, NCI-H716, RKO, SW48, SW620
Prostate cancer 22Rv1, CL-1, DU145, LNCap Clone FGC, PC-3
Bladder HT-1197, HT-1376, RT4, SCaBER, SW780, T24
Ovarian cancerES-2, HO-8910PM, PA-1, SK-OV-3, OVCAR-3
Endometrium / HysterocarcinomaAN3 CA, HEC-1-A, ME-180, MFE-280
Skin cancer cellA431
MelanomaA375, B16, A2058, C32, HMCB, SK-MEL-30, MDA-MB-435s
Osteosarcoma cellsMG-63, SJSA-1
Sarcoma S-180
Muscles, stripes SJCRH30
Myeloma KMS-11, KMS-26, RPMI-8226
Leukemia/lymphomaU937, THP-1, MV-4-11, HEL, TF-1a, ML-2, HL-60, L1210, K562, KARPAS-299, Daudi, Raji, Ramos, ARH-77, KMS- 12-BM, KG-1

Digestive system disease model

Medicilon provides various effective animal models (renal failure model, anemia animal model, gastric acid secretion animal model, gastric ulcer model, etc.) according to customer needs to test the effectiveness of drugs. Conventional diseases of the digestive system include: gastric acid secretion, gastric ulcer, renal failure, etc. Animal experiments are carried out in rats. see more

diseaseThe Digestive system disease modelThe Test animal
Renal failureThe Nephrectomy (5/6)The Rat
anemiaThe Renal failure induction The Rat
Gastric acid secretionThe Histamine gastric acid secretion model The Rat
The Pylorus ligation model of gastric acid secretion The Rat
The Ethanol gastric ulcer model The Rat
Gastric ulcerAspirin gastric ulcer model The Rat

Endocrine and Metabolic Disease Model

Medicilon provides a variety of effective endocrine disease models and animal models of metabolic diseases according to customer needs to test the effectiveness of drugs. Conventional endocrine diseases and metabolic diseases include: diabetes, obesity, dyslipidemia, etc. Animal experiments are conducted with large mice and hamsters. see more

DiseaseEndocrine and Metabolic Disease ModelAnimal
DiabetesStreptozotocin DiabetesMice
Spontaneously diabeticdb/db, ob/ob mice
Obese mice induced by high-fat diet DIO mice
Obesity Hereditarydb/db, ob/ob mice
Obese mice induced by high-fat dietDIO mice
Dyslipidemia High fat/cholesterolHamster

Inflammation and immune disease models

Medicilon provides various effective inflammatory disease models and animal models of immune diseases according to customer needs to test the effectiveness of drugs. Conventional inflammation and immune diseases include: acute inflammation, arthritis, experimental allergic encephalomyelitis, etc. Animal experiments are conducted with large mice. see more

Nervous system disease model
Medicilon provides a variety of effective animal models (depression animal models, Parkinson's disease animal models, psychotic animal models, etc.) according to customer needs to test the effectiveness of drugs. Routine neurological diseases include: psychosis, Parkinson's disease, depression, pain (central), etc. Animal experiments are conducted with large mice and guinea pigs. see more

Contact us

Email: Marketing@medicilon.com

Phone: 021 58591500

The relevant content of the above disease animal models is officially provided by Medicilon.

Related Articles:

Medicilon Tumor Modeling Service

Nude mice tumor formation experiment

Animal model of diabetes melitus

Medicilon Drug Screening Model Service

标签：

评论

发表评论

此博客中的热门博文

What is preclinical testing?

In the process of  preclinical testing  of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a  preclinical research  phase followed, before which, as described above, the potential toxicity of the compou
发表评论
阅读全文

Inventory of the three major in vitro pharmacokinetic research methods

  The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d
发表评论
阅读全文

Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in  Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati
发表评论
阅读全文