跳至主要内容

Medicilon's Synthetic Chemistry

 Our synthetic chemistry team has broad and in-depth expertise in synthetic organic chemistry. We use independent synthetic route design for complex molecules. An AI system assists with this design process, as well as performing reaction outcome prediction, quotation, and more.

Over the years, the team has developed and honed the skills to resolve even the most demanding synthesis-related challenges. We take a responsive project management approach and practice effective communication with each other and our clients.

Scientific ethics are of the utmost importance in our synthetic chemistry division, and we strive to maintain the strongest IP protection and highest standards for data integrity. In addition, all of our projects follow green chemistry principles.

drug discovery

Services

  • High Quality Compound Synthesis from mg to kg.
  • Synthesis of Reagents, Intermediates, Building Blocks, Reference Compounds, Metabolites and Impurities.
  • Scale-Up to non-GLP drug substances.
  • Development and Synthesis of PROTAC Drug Molecules.

Thechemistry synthesis service comes with weekly updates, final reports and ordered amounts of the compound under strict confidentiality. The final reports contain sufficient information for you to readily repeat the chemistry in house if needed.


Contact Us:

Email: marketing@medicilon.com

Tel: +44 1223 981 792(Europe)    +86 021 5859 1500

Website: www.medicilon.com


评论

此博客中的热门博文

Custom Synthesis

Medicilon has synthesized over 10,000 individual compounds from gram to kilogram quantities, and many compounds are synthesized with more than ten synthetic steps. The overall synthesis success rate is over 95%. High quality products from mg to kg scale Reagents, intermediates, building blocks, and scaffolds Preparation of API or reference standards Development of synthetic routes for impurities and metabolites   On-site analytical support Product delivered with COA Medicilon offers integrated drug discovery services -- Chemistry, Biology & Preclinical Services

In Vitro Enzyme Activity Assay

  Kinases play extensive and important roles in signal transduction and co-ordination of complex functions. Currently, about 300 kinase inhibitors have been approved for marketing, among which receptor tyrosine kinase (RTK) inhibitors are the main ones. Medicilon provides high-quality kinase profile screening and has one-stop kinase research services from assay development, high-throughput screening to selectivity analysis. In addition, Medicilon provides many other enzyme activity screens. Wide Variety Provides 200+  in vitro  enzymatic detection methods; 100+ kinases, including CTK, RTK, AGC, CMGC and other kinase families as well as important common mutations Project Flexibility Various types of plates for screening, such as 96 and 384; Multiple flexible kinase profiles, including TK kinase family, CDK kinase family, etc., to meet different customer customization needs. Various Methods Fluorescence detection; Chemiluminescence detection; Absorbance detection LanthaScr...

Pharmacokinetics Services

Pharmacokinetics Services Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Preclinical Pharmacokinetics Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability CYP 450 inhibition Plasma protein binding studies Distribution studies Excretion studies Prediction an...