Medicilon's Synthetic Chemistry

Our synthetic chemistry team has broad and in-depth expertise in synthetic organic chemistry. We use independent synthetic route design for complex molecules. An AI system assists with this design process, as well as performing reaction outcome prediction, quotation, and more.

Over the years, the team has developed and honed the skills to resolve even the most demanding synthesis-related challenges. We take a responsive project management approach and practice effective communication with each other and our clients.

Scientific ethics are of the utmost importance in our synthetic chemistry division, and we strive to maintain the strongest IP protection and highest standards for data integrity. In addition, all of our projects follow green chemistry principles.

drug discovery

Services

High Quality Compound Synthesis from mg to kg.
Synthesis of Reagents, Intermediates, Building Blocks, Reference Compounds, Metabolites and Impurities.
Scale-Up to non-GLP drug substances.
Development and Synthesis of PROTAC Drug Molecules.

Thechemistry synthesis service comes with weekly updates, final reports and ordered amounts of the compound under strict confidentiality. The final reports contain sufficient information for you to readily repeat the chemistry in house if needed.

Contact Us:

Email: marketing@medicilon.com

Tel: +44 1223 981 792（Europe） +86 021 5859 1500

Website: www.medicilon.com

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What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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