Taking the Responsibility and Praying for the Peace; Medicilon helps to fight the coronavirus by providing funds and technology

During the Spring Festival, China has been facing a difficult time as the coronavirus spread all over the country. In order to stop the coronavirus, we look forward to the effective prevention and control to stop the outbreak of the virus and the symptomatic treatment. We also hope the anti-virus vaccines and drugs could be developed and put into use as soon as possible. Medicilon involuntarily steps forward at this critical moment. As a new drug R&D enterprise and to show the social responsibility, we have funds, technology and equipment to fight the outbreak of the coronavirus with professionalism.

Technology Assistance: Medicilon provides drug safety evaluation research for coronavirus vaccine R&D at no cost, with an estimated R&D cost of RMB 4 million

On January 31, Medicilon, the team of Dr. Chen Ling of the State Key Laboratory of Respiratory Diseases (SKLRD) and Guangzhou nBioMed have reached a scientific research collaboration agreement. The three parties will establish a strategic collaborative partnership to integrate the advantages and strength of all parties to develop the new coronavirus vaccine.

SKLRD is the only state key laboratory in the field of respiratory disease research in China, relying on the Guangzhou Medical University and was approved by the Ministry of Science and Technology in October 2007. The first director of the laboratory was Academician Dr. Zhong Nanshan, who is the Chinese epidemiologist and pulmonologist who discovered the SARS coronavirus in 2003.

Medicilon plans to invest RMB 4 million in research collaboration with the above-mentioned laboratories. In addition, Medicilon will also provide preclinical drug safety evaluation for the development of new coronavirus vaccines for free. With its own innovative research and development technology platform, the fastest Degree to assist the vaccine development process, so that the vaccine can be put into use as soon as possible. With our own innovative research and development technology platform, this will help the vaccine development process at the fastest speed, so that the vaccine can be put into use as soon as possible. The three parties collaboration was docked by Professor Peng Shuangqing, VP of Preclinical, who was the key person in charge of the safety assessment of the Ebola virus vaccine. In the efforts to combat the epidemic and to actively collaborate with the laboratories, Medicilon will continue to adhere to the “Focus on Innovation and Dedicated Service”.

Funding Support: Medicilon donates RMB 1 million to Shanghai Red Cross Foundation to fight the epidemic

While developing the vaccine, we will not forget the frontline staff who is fighting the coronavirus and infected patients. On February 1, Medicilon donated RMB 1 million to the Shanghai Red Cross Foundation’s special donation project for “New Coronavirus Infected Pneumonia Epidemic Prevention and Control Project” in order to ease the problem of material shortage in Wuhan, Hubei. The donation gives our hearts and respects to the doctors and nurses!

What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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