跳至主要内容

Medicilon Appoints Dr. Liu Jian as President of Drug Discovery Division

 Medicilon, a one-stop pharmaceutical preclinical R&D service platform CRO, recognizes the importance of drug discovery as the cornerstone of new drug innovation. With extensive expertise in modern synthetic chemistry, Medicilon excels in various cutting-edge areas of pharmaceutical research, including chiral drugs, glycochemistry, antibodies and antibody-drug conjugates (ADC), nucleoside/nucleotide drugs, and oligonucleotide drugs (such as RNAi). Additionally, Medicilon has made significant advancements in PROTAC technology and established a progressively improved BSL-2 laboratory facility.

With the development of the pharmaceutical industry and the widespread adoption of artificial intelligence, the market potential for drug discovery is enormous. The addition of Dr. Liu Jian, a seasoned pharmaceutical research scientist, will empower Medicilon Drug Discovery division to revolutionize drug discovery model and bring new imagination to new drug discovery and development.

Recently, Shanghai Medicilon Inc. (Medicilon) appointed Dr. Liu Jian as the President of Drug Discovery Division.

Jian Liu.webp

Dr. Liu Jian holds a Bachelor's degree in Chemistry from Peking University, a Master’s degree in Chemical Engineering from Tsinghua University, and a Ph.D. in Computational Chemistry and Organic Chemistry from the University of California, Los Angeles (UCLA). He subsequently conducted postdoctoral research at the University of California, Irvine, and the University of Pennsylvania.  In 2018, Dr. Liu Jian served as the President of the Sino-American Pharmaceutical Professionals Association (SAPA) and is currently the Chairman of the board of directors of SAPA.  In 2019, he was awarded the "Outstanding 50 Asian American in Business " by the Asian-American Business Development Center in New York and was elected as one of the 12 most influential Chinese-Americans in New Jersey in 2019.

With over 20 years of experience in the field of innovative drug development, Dr. Liu Jian has made significant contributions. Under his leadership, the team has invented and submitted10 preclinical candidates (PCCs), which have entered Phase I, II, and III clinical trials. He has filed over 72 patent applications, with 21 patents already granted.  Dr. Liu Jian also possesses profound academic achievements, having published a total of 47 articles in international academic journals and serving as a reviewer for several international academic journals.

Dr. Liu joined the industry in 2001 and has worked for Merck for nearly 20 years. He has been primarily involved and leading the R&D of novel small molecule drugs for various diseases, including osteoporosis, obesity, diabetes, cardiovascular disease, cancer, immune disease, antiviral and antibacterial and pain. He started as a Senior Research Chemist and worked his way to the Principal Scientist and External Discovery Chemistry Lead, earning the "Merck Excellence Award" four times. He later served as CSO and Operations Director at Jiangsu Hengrui Pharmaceutical USA Drug Discovery Center (EBI), where he led the development of new drugs for cancer, immune diseases, osteoarthritis, and neurodegenerative diseases. Recently, he became the CEO of Silexon AI, responsible for building the company's artificial intelligence platform and empowering innovative drug research.

Dr. Liu Jian, President of Drug Discovery Division of Medicilon, said, “It's a great honor to be part of Medicilon. Over the past 19 years, Medicilon has deeply cultivated the preclinical research and development field and established a rare one-stop pharmaceutical preclinical research and development service platform in China. It has also aimed at cutting-edge technologies worldwide and continued to drive technological innovation. In the future, I hope to lead the team in the Drug Discovery Division to focus on efficient and high-quality new drug development, establish and improve various technical platforms for innovative drug research and development, including AIDD and structural biology, peptide and cyclic peptide drug development, synthetic biology, and nuclear medicine development. By realizing Medicilon one-stop service experiment from target research recommendation to IND application, we could empower the discovery of more innovative drugs for the benefit of patients!"

Dr. Chen Chunlin, the Founder and CEO of Medicilon, said, “Welcome Dr. Liu Jian to join Medicilon. We believe that his extensive academic background, outstanding leadership ability and rich R&D experience in the field of drug discovery will bring Medicilon more professional and cutting-edge innovative drug development technology , as well as advanced industry insights and strategic guidance crucial to Medicilon to next stage of development.

About Medicilon:
Medicilon was established in 2004 with its headquarters located in Shanghai. It is a leading Contract Research Organization (CRO) specializing in comprehensive preclinical research and development services in the field of biomedicine. We have established a comprehensive service; technology platform, which integrates compound synthesis, compound activity screening, structural biology, CMC, pharmacodynamics evaluation, pharmacokinetics and toxicological safety evaluation. On November 5, 2019, Medicilon was officially listed on the Science and Technology Innovation Board, becoming the first pharmaceutical CRO company to be listed on the board (Stock Code: 688202).

评论

此博客中的热门博文

What is preclinical testing?

In the process of  preclinical testing  of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a  preclinical research  phase followed, before which, as described above, the potential toxicity of the compou

Inventory of the three major in vitro pharmacokinetic research methods

  The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

Enzyme Activity Assay Service

  Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays  are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various  enzyme activity assays  for  kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a  large category of bio-molecules  that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modified molecules products with high sp