Five times in a row! Medicilon was shortlisted in the "2022 China CXO Enterprises Top 20 List"

On June 27, the 2022 China Pharmaceutical Industry Top 100 Series List was released. Shanghai Medicilon Inc. was once again shortlisted in the "China CXO Enterprises Top 20 List".

Being on the list for five consecutive times is a high affirmation and praise from industry authorities for the comprehensive strength of Medicilon's one-stop biopharmaceutical preclinical R&D service platform. It is also the recognition and encouragement of the sustainable development of Medicilon in the future!

2022 China CXO Enterprises Top 20 List.webp

"China's Top 100 Pharmaceutical Industry List Series" is initiated and hosted by Menet.com.cn, a leading platform for China's pharmaceutical and health information. It aims to set a benchmark for china pharmaceutical industry enterprises to enhance their comprehensive strength and expand brand effectiveness, demonstrate the excellence of the pharmaceutical brand industry, and guide the steady, rapid and sustainable development of the pharmaceutical and health industry. This list is selected from the two most important factors, innovation and professional promotion. The selection process has received high attention and active participation from professional research institutions, industry experts and colleagues, which shows its professionalism and authoritative.

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What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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Enzyme Activity Assay Service

Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various enzyme activity assays for kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a large category of bio-molecules that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modified molecules products with high sp

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