Toxicokinetics Test Service Company

“ADME” or “Toxicokinetics” is the process of studying the body’s absorption, distribution, metabolism, and excretion of foreign chemicals.

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Toxicokinetic absorption, distribution, metabolism, excretion

The toxicokinetics study used repeated doses of the toxicity test dose to study the dynamic changes of drugs in vivo, and obtained pharmacokinetic data. It is usually carried out in conjunction with repeated administration of toxicity tests. If appropriate parameters are determined, repeated tests can be avoided. Toxicokinetics is an integral part of the design of non-clinical trials. In understanding the results of toxicity studies and comparing them with clinical data to evaluate safety for humans, the focus is on interpreting the results of toxicity tests and increasing the value of safety assessment data. The purpose of the toxicokinetics study is to know the degree and duration of systemic exposure of the test substance at different dose levels in the toxicity test, and to predict the potential risk of the test substance in human exposure.

At present, the Medicilon Toxicokinetics Test Center has carried out comprehensive reproductive toxicity tests (paragraphs I, II, III), genotoxicity tests (Ames, micronucleus, chromosome aberrations), local toxicity tests, immunogenicity tests, Studies on safety pharmacology, toxicokinetics, carcinogenesis, etc.

The main values of toxicokinetics research in safety evaluation are:
(1) Describe the systemic exposure of the test substance and/or its metabolites in the toxicity test and its dose and time relationship with the toxic reaction; evaluate the test substance and/or its metabolite in different animal species, sex, age, Toxicity of body status (eg pregnancy status); Evaluate the rationality of animal species selection and medication regimen for non-clinical toxicity studies.
(2) Improve the predictive value of animal toxicity test results for clinical safety evaluation. Evaluating the target site toxicity (such as liver or kidney toxicity) caused by the accumulation of the test substance based on the exposure amount helps to provide quantitative safety information for the subsequent safety evaluation.
(3) Comprehensive drug efficacy and exposure and toxicity and exposure information to guide the design of human trials, such as initial dose, safety range evaluation, etc., and guide clinical safety monitoring according to the degree of exposure.

Exposure Assessment Services

Plasma protein binding
Tissue uptake
Receptor properties
Species differences in metabolic characteristics
Pharmacological activity of metabolites
Immunogenicity and toxicology

Research Content of Pharmacokinetics and Toxicokinetics:

Our Staff

Design the dosing regimen of the toxicokinetic test
Collect samples in time according to the frequency required for exposure assessment
Analysis of analyte and biological matrix (biological fluid or tissue)
Data statistics and evaluation
Write an experimental report based on complete toxicokinetic data

Phone: 021 58591500

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What is Toxicokinetics?

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration. The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies, ADCs , mRNA vaccines , small nucleic acid drugs , PROTAC , and CGT technical service platform that have helped 421 INDs obtain clinical approval. It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

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What is Toxicokinetics?

Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms toxicokinetics , pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...

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