跳至主要内容

What is chemical synthesis and what are chemical synthetic drugs?

What is synthesis?

Synthesis refers to transforming a substance with a relatively simple composition into a sense with a complex design through a chemical reaction. Together with decomposition and replacement, it is also called three types of a chemical reactions.

What is chemical synthesis?

Chemical synthesis, also known as chemical synthesis, synthetic chemistry is the foundation and core of organic chemistry, inorganic chemistry, medicinal chemistry, polymer chemistry, material chemistry, and other disciplines. This course mainly introduces new concepts and new methods in the field of inorganic synthesis and organic synthesis. The organic synthesis part explicitly teaches the basic knowledge of organic synthesis and route design, modern organic synthesis methods, green synthetic chemistry, biomimetic synthesis, etc. The role of inorganic synthesis mainly teaches high-temperature synthesis, low-temperature solid-phase synthesis chemistry, hydrothermal and solvothermal synthesis, high-pressure synthesis and technology of inorganic materials, application of CVD in inorganic synthesis and material preparation, inorganic synthesis under microwave and plasma, Synthetic formulation chemistry of bit compounds, synthetic chemistry of cluster compounds, synthetic chemistry of metal-organic compounds, synthetic chemistry of porous materials, preparation chemistry of ceramic materials, preparation chemistry of inorganic membranes, synthetic crystals, etc.

Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds.

Synthetic chemistry is a series of chemical reactions to obtain one or more products. Synthesis usually appears as one or more reactions manipulated by physical or chemical means. In modern laboratory applications, synthesis often implies that the entire process is reliable, reproducible, and usable across multiple laboratories.

What are chemical synthetic drugs?

Chemical synthetic drugs are chemical drugs. Generally, it refers to synthesizing a single compound using chemical synthesis. Chemically synthesized drugs have already become the "backbone product" of today's pharmaceutical industry. 80% of the top 50 best-selling drugs in the world are synthetic drugs.

Refers to the raw materials of compounds with relatively simple structures or natural products with a specific basic design, which is prepared through a series of reaction processes and has preventive, therapeutic, and diagnostic functions on the human body. With the development of organic chemistry, pharmacology, and the chemical industry, synthetic chemical drugs are developing rapidly. Their variety, output, and output value all occupy the leading position in the pharmaceutical industry. There are thousands of chemically synthesized drugs in clinical use worldwide.

Related Articles:

Chiral Drug Synthesis

Nine Development Trends of Chemical Synthetic Drugs

Six Directions of Chemical Synthesis Drug Research and Development

Chemical Synthesis

In chemistry, chemical synthesis is the process of producing desired compounds through chemical reactions. Typically, chemical reactions until the expected product are obtained in association with each point in the sequence, chemistry, and physical specific isolation, purification, and analysis are performed in multiple steps. The results must be reproduced, verified, and confirmed by other experimenters.

Chemical synthesis begins with the selection of starting materials and reagents. Various chemical reactions can be used to obtain target products. There are two ways of expressing the quantity of development: the yield expressed in mass and the yield expressed as a percentage of the theoretical amount obtained from the starting material.

In preparing complex compounds from simple compounds, multi-step operations require much time and labor until the target product is synthesized. In particular, multi-step chemical synthesis to produce natural products such as physiologically active substances or theoretically interesting organic compounds from only commercially available simple compounds is called total synthesis. Total synthesis is a purely synthetic chemical process; on the other hand, using natural products extracted from plants, animals, fungi, etc., as raw materials are called semi-synthesis.

It is awarded for outstanding organic synthesis technology. The Nobel Prize in Chemistry is awarded to those who have discovered a way to synthesize precious and complex compounds, such as Robert Burns Woodward.

Various pathways can be considered for converting compound A to product B, which are referred to as "synthetic strategies." In multistage reactions, chemical transformations are performed sequentially on a substrate, and in multicomponent responses, a single product is obtained from multiple reactants. One-pot synthesis does not isolate or purify products but chemically transforms reaction products sequentially.

评论

此博客中的热门博文

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

  On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration.  The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages      Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies,  ADCs ,  mRNA vaccines ,  small nucleic acid drugs ,  PROTAC , and  CGT technical service platform  that have helped 421 INDs obtain clinical approval.  It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

  In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

What is Toxicokinetics?

Toxicokinetics  is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms  toxicokinetics ,  pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...