Shanghai Medicilon Inc.

  As a provider of global chemical services, Medicilon has a strong analytical chemistry team to support   synthetic chemistry services.   We are committed to providing customers with the highest quality and most valuable products and services through prolific, fast, problem-solving and active communication. Our team has received excellent professional training, keeps close contact and interaction with customers, communicates in time to ensure the smooth progress of the project, and makes concerted efforts to achieve the project goals specified by the customer. In FTE’s service model, we design a synthetic route for the customer’s target molecule, and complete the synthesis and delivery of the compound on time, quality and quantity. These compounds include reference compounds, metabolites, reagents, intermediates, molecular fragments and impurities. Intermediate Synthesis Pharmaceutical Intermediate Synthesis Medicilon synthesizes various small molecule chemical substance...

As an important part of the development of the pharmaceutical industry, chemically synthesized drugs are the main source of drug candidates, as well as a high-input, high-output and high-efficiency work. The main directions for  chemical synthesis drug research and development  are as follows.          ❖      Medicilon’s Synthetic Chemistry Services Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds. Related Articles: Medicilon's Custom Peptide Synthesis Services The Special Effects Channel Leading to the Fight Against the New Crown - Paxlovid Dr. Ma Jianguo: Adding "Green" to API Synthesis Research and Develop New Chemical Entity Drugs New Chemical Entities (NCE) drugs refer to newly discovered drugs with new che...

  As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals or   synthetic organic compounds , effective monomers extracted from natural drugs, or antibiotics obtained by fermentation. In the future, the development of chemically synthesized drugs presents the following development trends: Discover new lead compounds from medicinal plants, modify their structures, and invent new drugs Chinese herbal medicine has been used for thousands of years, and very valuable experience has been obtained in the treatment of various diseases including tumors. Abundant Chinese herbal medicine resources also provide an important material basis for the search for new anti-cancer dru...

  In 1883, E. Fischer and F. Jourdan treated pyruvate with 1-methylphenylhydrazone with HCl alcohol solution to obtain 1-methylindole-2-carboxylic acid. After this discovery, the Fischer indole synthesis reaction became a very significant method for the synthesis of substituted indoles. The Fischer indole synthesis reaction is a simple and rapid synthesis method for arylhydrazones obtained from the reaction of aldehydes or ketones with arylhydrazones.  The drug discovery of Medicilon mainly include chemistry (synthetic chemistry, medicinal chemistry) and biology. Among them, our chemistry team can undertake multi-dimensional business cooperation such as custom synthesis of compunds, compound library construction, SAR compound synthesis and screening, compound structure and biological activity optimization. This reaction is followed by cyclization to generate polysubstituted indoles. The phenylhydrazone generated in the reaction is heated and rearranged under acid catalysi...

 Many people are curious about chemically synthesized drugs. In fact, in our lives, most of them are chemically synthesized drugs. The common ones are aspirin (acetylsalicylic acid), phenacetin, benzocaine, compound methoxy Naming and others. So how are they produced? The production methods of chemically synthesized drugs include total chemical synthesis, semi-synthesis, and chemical synthesis combined with microbial (enzyme-catalyzed) synthesis. What are the specific chemically synthesized drugs and what are the production methods of chemically synthesized drugs? Take a look at the article! 1. What are chemically synthesized drugs ? Chemically synthesized drugs refer to chemically synthesized drugs that are researched and produced according to chemical laws under the guidance of chemical theory. Generally speaking, it has a quick curative effect and a clear effect on disease treatment. The human body is a complex system, and chemically synthesized drugs lack the analysis and ...

  Chiral drugs   refer to drugs that contain chiral centers (including chiral carbon, chiral nitrogen, chiral sulfur, etc.) in their molecular structure. In January 1992, the FDA promulgated the “Development of Stereoisomer Drugs” technical research guidelines, giving guidance on the work that needs to be done in the research of stereoisomer drugs. In December 2006, the CFDA issued the “Technical Guidelines for the Quality Control of Chiral Drugs”, which provided detailed guidance on the research work that needs to be carried out in the   synthesis process , structural confirmation and quality control research of chiral drugs, and indicated for the research of chiral drugs. Up the direction. As a special kind of chemical drugs, chiral drugs should not only follow the “Guiding Principles for the Research of Chemical Drug Preparation Processes”, but also combine the introduction of chiral centers to establish appropriate process control indicators for monitoring. The config...

  The oxidative cleavage of olefins is an important transformation in organic synthesis to obtain carbonyl functional groups such as ketones and aldehydes. The current used approaches, such as ozonolysis and Lemieux-Johnson Oxidation suffer from many significant limitations. Thus the development of a mild, general, and practical approach is still highly warranted. Oxidative Cleavage of Alkenes [1] A recent report from Parasram group (J. Am. Chem. Soc. 2022, 144, 15437.) indicated a visible light-induced anaerobic cleavage of alkenes by using economical and bench-stable nitroarenes as oxygen transfer reagents. The authors used 4-fluorostyrene as the control olefin to optimize the reaction conditions. They found 4-CN-nitrobenzene was the best nitroarene for such transformations. A few other nitroarenes bearing strong electron-withdrawing group gave satisfactory results, while nitroarene bearing electron-donating group gave poor conversion. Optimization of reaction condition [1] By us...

  Recently, CGeneTech (Suzhou) Co., Ltd. (CGeneTech) submitted the DPP-4 inhibitor Sitagliptin, for the treatment of type 2 diabetes, to the National Medical Products Administration (NMPA) for approval. Shanghai Medicilon Inc. (Medicilon), as a partner of CGeneTech, provided Sitagliptin with comprehensive  preclinical research services  in compliance with GLP regulations, including  pharmacodynamic research ,  pharmacokinetic research  and  safety evaluation , as well as Phase I clinical bioanalysis to facilitate its efficient and high-quality R&D. Medicilon Preclinical Research Platform Help drug research and development faster, better and cost-efficient Efficiency comes from collaboration, and success comes from experience.  Medicilon, as a one-stop comprehensive preclinical research and development service CRO for biopharmaceutical, has been continuously improving the scientific and technological innovation for 19 years, providing customize...