跳至主要内容

Nine Development Trends of Chemical Synthetic Drugs

 As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals or synthetic organic compounds, effective monomers extracted from natural drugs, or antibiotics obtained by fermentation. In the future, the development of chemically synthesized drugs presents the following development trends:

Discover new lead compounds from medicinal plants, modify their structures, and invent new drugs

Chinese herbal medicine has been used for thousands of years, and very valuable experience has been obtained in the treatment of various diseases including tumors. Abundant Chinese herbal medicine resources also provide an important material basis for the search for new anti-cancer drugs. Natural products are the largest and best source of medicines. Not only are the medicines used in various traditional medicines in the world belong to natural sources, even if they are used in modern medicine. The number of natural-derived compounds in the chemical drugs in China also exceeds 30%, and more drugs are produced by structural modification and transformation of natural products as lead compounds. The diversity of the structure and biological activity of natural products can not only directly provide new drugs or drug-leading compounds, but also provide inspiration for chemical synthesis and structural modification. Discovering novel lead compounds with antiviral and antitumor activity from medicinal plants is one of the important directions for the development of antiviral and antitumor drugs.

Medicilon can undertake the synthesis of special reagents, intermediates and molecular fragments, preparation of standard products, synthesis design and preparation of impurities or metabolites, synthesis of stable isotope internal standards and synthesis of tritiated compounds.

Medicilon can provide customers with high-efficiency and maximum production capacity preparation process optimization services, saving customers time and cost, and producing reliable and cost-effective intermediates and API products for customers. The main research and development projects include: chemical drug synthesis process Optimization, preparation process optimization, etc.

It has been difficult to discover new structural types of antibiotics from natural sources. The increase in the resistance of microorganisms to antibiotics and the unreasonable use of antibiotics have made the service life of an antibiotic shorter and shorter.

Nowadays, antimicrobial drug resistance is everywhere, and it may affect people of any age in any country. Many of the medical breakthroughs made in the last century may be lost due to the spread of antimicrobial resistance, and previously curable infectious diseases may become untreatable and spread throughout the world. Antimicrobial drug resistance is a global problem. In the past few years, the use and misuse of antimicrobial drugs has increased the number and types of drug-resistant microorganisms. As a result, multiple infectious diseases may become uncontrollable again. With the increase in global trade and travel, drug-resistant microorganisms may rapidly spread to every corner of the world.

The emergence of combinatorial chemistry has greatly accelerated the synthesis and screening of compounds

The application of combinatorial chemistry technology to obtain new compound molecules is a development of bionics. It assembles some basic small molecules into different combinations to build a chemical molecule library with a large number of compounds, and then combines high-throughput screening to find some active lead compounds.

Organic compounds are still the most important source of chemically synthesized drugs.

Most of the drugs are organic compounds, and the current synthetic drugs are also prepared by organic chemistry synthetic methods. At present, chemically synthesized drugs are still the most effective, most commonly used, largest and most important therapeutic drugs. Nowadays, the subject of new drug research by major pharmaceutical companies in the world is still chemically synthesized drugs

The gradual formation of the discipline of instrumental analysis (spectroscopy, chromatography) has accelerated the development of chemically synthesized drugs.

Entering the 21st century, a batch of inventions with advanced computer equipment, continuous improvement of separation and analysis methods, especially the further miniaturization of analysis methods, will further improve the quality of chemically synthesized drugs and further accelerate the development speed.

The effective pharmacological performance of chemically synthesized drugs is more specific.

Pharmacology is further branched into molecular pharmacology, biochemical pharmacology, immunopharmacology, receptor pharmacology, etc. In the future, chemical synthesis of drugs will closely promote the development of pharmacology, and the progress of pharmacology will promote the development of chemical synthesis of drugs. A more specific direction will make it not only have better medicinal effects, but also reduce toxic and side effects.

The research and development of new drugs for rational drug design using computers has shown good development prospects.

In the 21st century, the three-dimensional structure of enzymes, receptors, and proteins will be elucidated one by one, which lays a solid foundation for the development of new chemically synthesized drugs by using these “biological targets” that have been clarified for rational drug design. .

Synthetic drugs for the prevention and treatment of important diseases such as cardiovascular and cerebrovascular diseases, cancer, viruses and AIDS, senile diseases, immunity and heredity are new drugs that need to be developed in the 21st century.

The rapid progress of molecular biology technology and the research achievements of human genomics will have a significant impact on clinical medication. It will not only help discover a new type of trace endogenous substances, such as active proteins, cytokines and other drugs, but also The research of chemical synthetic drugs, especially the provision of new targets, has laid an important foundation. Chemical drugs are a class of special chemicals with a clear structure that can prevent, treat, or diagnose diseases, or regulate human functions, improve body quality, and maintain physical health. They are closely related to humans and are part of the applications in human daily life. As a means of synthesizing chemical drugs, chemically synthesized drugs will become more and more important in the future.

标签：

评论

发表评论

此博客中的热门博文

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

  On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration.  The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages      Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies,  ADCs ,  mRNA vaccines ,  small nucleic acid drugs ,  PROTAC , and  CGT technical service platform  that have helped 421 INDs obtain clinical approval.  It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...
发表评论
阅读全文

A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

  In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...
发表评论
阅读全文

What is Toxicokinetics?

Toxicokinetics  is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms  toxicokinetics ,  pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...
发表评论
阅读全文