Medicilon Intermediate Synthesis Service

As a provider of global chemical services, Medicilon has a strong analytical chemistry team to support synthetic chemistry services. We are committed to providing customers with the highest quality and most valuable products and services through prolific, fast, problem-solving and active communication. Our team has received excellent professional training, keeps close contact and interaction with customers, communicates in time to ensure the smooth progress of the project, and makes concerted efforts to achieve the project goals specified by the customer. In FTE’s service model, we design a synthetic route for the customer’s target molecule, and complete the synthesis and delivery of the compound on time, quality and quantity. These compounds include reference compounds, metabolites, reagents, intermediates, molecular fragments and impurities.

Pharmaceutical Intermediate Synthesis

Medicilon synthesizes various small molecule chemical substances such as reference compounds, pharmaceutical intermediates, candidate drugs, impurities and metabolites for customers. The scale can range from milligrams to kilograms (including GMP quality). Our team is proficient in new route design and route optimization. With the proficient problem solving skills and the high success rate of the project, we are able to provide customers with the following high-quality chemical custom synthesis services:

Preparation of high-quality products from milligrams to kilograms
Synthesis of special reagents and pharmaceutical intermediates and preparation of molecular fragments
Preparation of APIs or related substances
Synthetic design and preparation of impurities and metabolites
Analysis support
Delivery of product analysis report

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Medicilon’s chemical department is mainly engaged in the research and development and process optimization of high value-added new pharmaceutical intermediates, the research and development and process optimization of fine chemicals and the synthesis of raw materials, and is especially committed to natural products, special reagents, pharmaceutical intermediates, and pharmaceutical intermediates required for the research and development of new drugs. As well as the laboratory synthesis and amplification of various sugar compounds, the company has a factory base and advanced test equipment. The company has a comprehensive literature retrieval system, highly specialized chemical synthesis and process development capabilities, and high-level synthetic technical personnel.

Pharmaceutical intermediates, generally speaking, refer to those key raw materials specifically used to produce drugs, such as the key intermediates 6-APA (6-aminopenicillanic acid), 7-ACA (7-amino Cephalosporan acid), 7-ADCA (7-aminodeacetoxycephalosporan acid), various cephalosporin side chains, and piperazine and its derivatives used in the production of quinolones, excluding those used Basic chemical raw materials used in drug production, such as ethanol and acetic acid.

Medicines can be divided into anti-cardiovascular drugs, anti-tumor drugs, endocrine system regulating drugs, antibiotics, etc. according to their uses, and each class of drugs contains a variety of drugs with different structures, such as: antibiotics including lactams, macrocyclic Esters, quinolones, chloramphenicol, etc. Since pharmaceutical intermediates are mainly used in the production of various drugs, they have a wide variety of types.

From the perspective of production, the pharmaceutical industry can be divided into two major categories: raw material drug production and preparation processing; raw material drug production can be divided into natural drugs and chemical drugs according to source, and can be divided into natural extracted drugs, biosynthetic drugs and chemically synthesized drugs according to production methods.

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This article is about the synthesis of pharmaceutical intermediates and pharmaceutical intermediates. For more details, please contact us.

What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Enzyme Activity Assay Service

Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various enzyme activity assays for kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a large category of bio-molecules that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modified molecules products with high sp

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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