What are chemically synthesized drugs? What are the synthetic methods of chemically synthesized drugs?

 Many people are curious about chemically synthesized drugs. In fact, in our lives, most of them are chemically synthesized drugs. The common ones are aspirin (acetylsalicylic acid), phenacetin, benzocaine, compound methoxy Naming and others. So how are they produced? The production methods of chemically synthesized drugs include total chemical synthesis, semi-synthesis, and chemical synthesis combined with microbial (enzyme-catalyzed) synthesis. What are the specific chemically synthesized drugs and what are the production methods of chemically synthesized drugs? Take a look at the article!

1. What are chemically synthesized drugs?

Chemically synthesized drugs refer to chemically synthesized drugs that are researched and produced according to chemical laws under the guidance of chemical theory. Generally speaking, it has a quick curative effect and a clear effect on disease treatment. The human body is a complex system, and chemically synthesized drugs lack the analysis and research of the molecular level of the human body itself. They lack the overall comprehensive investigation of the correlation of various parts of the human body. Therefore, although the therapeutic effect is obvious, it has the limitation of treating the head for headaches and treating feet for feet. Treatment characteristics, and often have side effects of varying degrees. So do you know what chemically synthesized drugs are? Chemically synthesized drugs have already become the "backbone product" of today's pharmaceutical industry. 80% of the top 50 best-selling drugs in the world are synthetic drugs. Such as aspirin (acetylsalicylic acid), phenacetin, benzocaine, compound methoxyphenamine, etc.

The drug discovery of Medicilon mainly include chemistry (synthetic chemistry, medicinal chemistry) and biology. Among them, our chemistry team can undertake multi-dimensional business cooperation such as custom synthesis of compunds, compound library construction, SAR compound synthesis and screening, compound structure and biological activity optimization.

2. What is the production method for chemically synthesized drugs?

Most of the production of chemical synthetic drugs adopts the batch method, which can roughly be divided into three types:

1. Total chemical synthesis. Most chemically synthesized drugs are made from basic chemical raw materials and chemical products through various chemical reactions, such as sulfa drugs and various antipyretic and analgesic drugs.

2. Semi-synthetic, some chemically synthesized drugs use natural products with a certain basic structure as intermediates for chemical processing, such as steroid hormones (see hormones), semi-synthetic antibiotics (see antibiotics), vitamin A, E, etc. (See vitamins).

3. Combining chemical synthesis with microbial (enzyme-catalyzed) synthesis, this method can make the production process of many medicines more economical and reasonable, such as the synthesis of vitamin C, steroid hormones and amino acids.