跳至主要内容

Fluorescence Probes Synthesis



Medicilon's fluorescent probes and labeling platforms can provide fluorescent probe design and synthesis services for scientific institutions, drug R&D companies, and other customers.

Design and synthesis steps
  • Fluorescent probes are tools used to detect, measure and analyze biomolecules, cells and tissues. They achieve these purposes by emitting and receiving fluorescent signals. Medicilon can complete the design and synthesis of fluorescent probes for biomolecules.
    Selection of target molecules and determination of target.Selection of fluorescent dyes.Design of molecular structure.Synthesize probe molecules.Testing the properties of probe molecules.
Custom synthesis
  • Medicilon's fluorescent probes and labeling platforms can provide fluorescent probe design and synthesis services for scientific institutions, drug R&D companies, and other customers. After years of development, Medicilon's fluorescent probes and labeling platforms have accumulated rich experience in the synthesis of high-quality fluorescent (phosphorescent) dyes, luminescent materials, contrast agents, and their applications in novel and classical fluorescent probes. In addition, Medicilon also supports the upstream and downstream development of fluorescent biological probes, aiming to provide customers with a complete solutions for multiple biomarker studies in-vivo (in-vitro), and provide customers with multi-field and multi-level R&D service support.
Applications
  • Fluorescent probes are widely used in biomedicine, drug research and development, environmental monitoring, chemical analysis and other fields.
    Cell imaging
    Fluorescent probes can be used for live cell imaging. Through the use of fluorescent probes, fluorescent probes with different properties can be used to monitor the imaging cell status of different organelles and metabolic processes. This can be applied in monitoring important biochemical processes such as cell apoptosis and reactive oxygen species generation.
    Drug screening
    Fluorescent probes can be used for protein analysis, such as protein inhibition, activation, binding, etc. The function of the protein can be monitored by observing changes in fluorescence intensity to determine whether the drug interacts with the proteins, providing a basis for further drug development.
    Drug development
    Fluorescent probes are also widely used in drug research and development, including drug absorption, metabolism, and pharmacodynamics. The properties of drug absorption kinetics can be interpreted by observing changes in fluorescence signals, providing support for further drug development.
标签：

评论

发表评论

此博客中的热门博文

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

  On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration.  The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages      Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies,  ADCs ,  mRNA vaccines ,  small nucleic acid drugs ,  PROTAC , and  CGT technical service platform  that have helped 421 INDs obtain clinical approval.  It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...
发表评论
阅读全文

A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

  In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...
发表评论
阅读全文

What is Toxicokinetics?

Toxicokinetics  is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms  toxicokinetics ,  pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...
发表评论
阅读全文