Isotope-labeled Internal Standards Synthesis

Medicilon provides synthesis services of standards and isotope internal standards, and offers professional services in the design, synthesis, preparation and release of radiolabeled compounds of synthetic routes.

At the same time, Medicilon has the capability of isotope pharmacokinetic analysis of innovative drugs and has served the new drug development and marketing applications of many pharmaceutical companies. Medicilon has an advanced laboratory capable of isotope pharmacokinetic analysis of innovative drugs and an integrated service platform integrating isotope synthesis, labeling, testing, and analysis, providing comprehensive technical support for the research and development of new drugs such as antibodies and vaccines.

Services include:

1. Synthesis services of standards and isotope internal standards
Medicilon’s Chemical Synthesis and Radiosynthesis Laboratory can provide short-term and rapid synthesis services of standards and isotope internal standards. Synthesis services include but are not limited to isotope labeling position selection, synthesis route optimization, isotope product purification and analysis, and isotope labeling biomacromolecule R&D services.
2. Pharmaceutical research and analysis services of radioisotope
Pharmaceutical research and analysis services of radioisotope, using ³H、¹⁴C 、³²P、³³P 、¹²⁵I、³⁵S、⁸⁹Zr and other radioactive isotopes for labeling experiments in the drug development process, including:
Distribution, metabolism and pharmacokinetics of drugs in vivoRadioreceptor assayRadioligand binding testRadioactive uptake testingCell growth testRadioimmunoassayImmunoradiation analysis, etc.
In addition,we have a radioisotope (¹²⁵I, ¹⁴C, ³H) research license for studying material balance and tissue distribution.
3. Synthesis of ¹⁴C and ³H radiolabeled compounds
Medicilon can provide synthesis of aromatic compounds, heterocyclic compounds, polypeptides, oligonucleotides, conjugates, and polymers, including chiral compounds, antibody-drug conjugates (ADCs), and their linkers.Medicilon can provide a wide range of analytical methods and develop special technologies (including GLP analysis) such as Infrared spectroscopy, mass spectrometry, liquid chromatography (radioactivity detection and polymer characterization), gas chromatography, NMR differential scanning calorimetry, thermogravimetric analysis and ICP-MS, bioburden test and XRPD analysis.

Advantage:

Rich experience in chemical synthesis combined with efficient isotopic labeling chemistry. Medicilon can provide customers with laboratories that comply with GLP and GMP standards to complete radiolabeled chemical projects. Medicilon tracks the progress of isotope labeling chemistry and can quickly provide customers with a variety of isotope labeling intermediates.

In Vitro Enzyme Activity Assay

Kinases play extensive and important roles in signal transduction and co-ordination of complex functions. Currently, about 300 kinase inhibitors have been approved for marketing, among which receptor tyrosine kinase (RTK) inhibitors are the main ones. Medicilon provides high-quality kinase profile screening and has one-stop kinase research services from assay development, high-throughput screening to selectivity analysis. In addition, Medicilon provides many other enzyme activity screens. Wide Variety Provides 200+ in vitro enzymatic detection methods; 100+ kinases, including CTK, RTK, AGC, CMGC and other kinase families as well as important common mutations Project Flexibility Various types of plates for screening, such as 96 and 384; Multiple flexible kinase profiles, including TK kinase family, CDK kinase family, etc., to meet different customer customization needs. Various Methods Fluorescence detection; Chemiluminescence detection; Absorbance detection LanthaScr...

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Fluorescence Probes Synthesis

Medicilon's fluorescent probes and labeling platforms can provide fluorescent probe design and synthesis services for scientific institutions, drug R&D companies, and other customers. Design and synthesis steps Fluorescent probes are tools used to detect, measure and analyze biomolecules, cells and tissues. They achieve these purposes by emitting and receiving fluorescent signals. Medicilon can complete the design and synthesis of fluorescent probes for biomolecules. Selection of target molecules and determination of target. Selection of fluorescent dyes. Design of molecular structure. Synthesize probe molecules. Testing the properties of probe molecules. Custom synthesis Medicilon's fluorescent probes and labeling platforms can provide fluorescent probe design and synthesis services for scientific institutions, drug R&D companies, and other customers. After years of development, Medicilon's fluorescent probes and labeling platforms have accumulated rich experience...

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Custom Synthesis

Medicilon has synthesized over 10,000 individual compounds from gram to kilogram quantities, and many compounds are synthesized with more than ten synthetic steps. The overall synthesis success rate is over 95%. High quality products from mg to kg scale Reagents, intermediates, building blocks, and scaffolds Preparation of API or reference standards Development of synthetic routes for impurities and metabolites On-site analytical support Product delivered with COA Medicilon offers integrated drug discovery services -- Chemistry, Biology & Preclinical Services

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Shanghai Medicilon Inc.

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